Preparation Of Aspirin
Introduction
Aspirin (acetylsalicylic acid) is an anti-inflammatory painkiller, which is extensively used, worldwide, for pain relief, to reduce inflammation and temperatures, and to reduce the risk of heart attacks and strokes.
Uses of aspirin
* Pain relief, particularly where there is inflammation involved, including dental pain and period pain (menorrhagia).
* Reducing temperature (as an antipyretic).
*Making the blood flow better through narrowed blood vessels.
It is prepared by the esterfication of the phenolic hydroxyl group of salicylic acid.
The structural formula for aspirin is:
Its empirical formula is C9H8O4
Equation
The equation for aspirin is:
C7H603 + (CH3CO)20 C9H804
Method
What I am going to do is
* Weigh out 2.0g of 2-hydroxybenzoic acid and place in a 50-cm3 pear shaped flask.
* Add 4-cm3 ethanoic anhydride to this.
* Add 5 drops of 85% phosphoric acid and swirl to mix. Do this in a fume cupboard.
* Reflux the mixture using a boiling water bath for 5 minutes.
* Add 2cm3 water in one portion down the condenser. The mixture should boil.
Introduction
Aspirin (acetylsalicylic acid) is an anti-inflammatory painkiller, which is extensively used, worldwide, for pain relief, to reduce inflammation and temperatures, and to reduce the risk of heart attacks and strokes.
Uses of aspirin
* Pain relief, particularly where there is inflammation involved, including dental pain and period pain (menorrhagia).
* Reducing temperature (as an antipyretic).
*Making the blood flow better through narrowed blood vessels.
It is prepared by the esterfication of the phenolic hydroxyl group of salicylic acid.
The structural formula for aspirin is:
Its empirical formula is C9H8O4
Equation
The equation for aspirin is:
C7H603 + (CH3CO)20 C9H804
Method
What I am going to do is
* Weigh out 2.0g of 2-hydroxybenzoic acid and place in a 50-cm3 pear shaped flask.
* Add 4-cm3 ethanoic anhydride to this.
* Add 5 drops of 85% phosphoric acid and swirl to mix. Do this in a fume cupboard.
* Reflux the mixture using a boiling water bath for 5 minutes.
* Add 2cm3 water in one portion down the condenser. The mixture should boil.
