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Some authors indicated that there might be a correlation between anaemia correction & delayed progression of CRF. A literature review is therefore proposed to find out whether the published literatures can provide an answer to the problem.

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Introduction

A literature review to find out whether correction of anaemia with erythropoietin in predialysis anaemic patients can slow the progression of renal damage. Module Number: P49210 Module Title: Advanced Research Design Student Name: Mohammed Nazmul Ahsan Student Number: 06108646 Tutor: Dr. Neil Wheeler Abstract The treatment of End Stage Renal Failure (ESRF) with dialysis and kidney transplantation is creating a huge pressure on the healthcare budget & staff all over the world. Till now, there is no known method that can slow the progression of this disease. Physicians & health authorities around the world are desperately looking for an approach that can slow the speed of progression of this medical condition. Different authors have suggested different approaches to address the problem. Some authors indicated that there might be a correlation between anaemia correction & delayed progression of CRF. A literature review is therefore proposed to find out whether the published literatures can provide an answer to the problem. Table of Contents 1. Introduction ........................................................ page 4 2. Title.................................................................. page 4 3. Study Problem......................................................... page 4 4. Relevance of the project...................................... page 5 5. Literature review................................................ page 5 6. Specific study aims and objectives......................... page 6 7. Methodology...................................................... page 6 8. Ethics............................................................... page 11 9. Resources......................................................... page 11 10. Time-plan......................................................... page 12 11. References...................................................... page 12 1. Introduction: Chronic Renal Failure (CRF) ...read more.

Middle

Correction of anaemia is an integral part of CRF management. Correction of anaemia reduces the risk of cardiovascular mortality and morbidity. Using erythropoietin to correct anaemia in CRF has now become the standard of care. However, there is no clear evidence that correction of anaemia slows the rate of renal damage in CRF. Some of the literatures indicate that there might be a correlation between correction of renal anaemia & progression of kidney damage. So, a review on the available literatures will be conducted to discover whether or not the use of EPO can slow the progression renal damage in CRF patients. 6. Specific Study Aim and Objectives 6.1 Question Can correction of anaemia with erythropoietin slow the progression of renal damage in CRF patients? 6.2 Aim To identify whether reversal of renal anaemia with erythropoietin slows renal damage in Predialysis CRF patients 6.3 Objectives 1. To understand whether erythropoietin can slow the progression of renal damage in CRF 2. To identify whether there is a relationship between Haemoglobin (Hb) or Haematocrit (Hct) level & renal function 7. Methodology 7.1 Paradigm & Methodology Without nominating a paradigm as the first step, there is no basis for subsequent choices regarding methodology, methods, literature or research design (Mackenzie & Knipe 2006). The proposed research belongs to a positivist paradigm which according to Brechin and Sidell (2000), is the research method that has evolved to understand, describe, explain and control the natural world, using observational and experimental methods to shore up our uncertain mental capacity by building in checks against bias. ...read more.

Conclusion

* Mind map analysis: As suggested by Hart (2001), a Mind-map analysis will be done. Mind Maps are more compact than conventional notes, often taking up one side of paper. This helps to make associations easily. A complete Mind Map may have main topic lines radiating in all directions from the centre. 8. Ethics As suggested by Beauchamp and Childress (2001), it will be made sure that the following duties towards the patients were ensured: * Autonomy * Beneficence * Non-maleficence * Justice As described by Hart (2001), using the literature on a topic the researcher is using the ideas, concepts and theories of other people. It is therefore the responsibility of the researcher to use the work of other in a way that that is balanced, fair and legal. This involves ensuring that the sources are cited correctly and, where, where necessary, not infringing copyright or even Data Protection Act. To perform duties toward the researchers following actions will be avoided: * Falsification * Fabrication * Sloppiness * Nepotism * Plagiarism 9. Resources The research will involve 1215 pound sterling: * 200 working hours of a research assistant @ 6 pound sterling = 1200 Pounds * Computer print-out: 200 pages @ 5 pence= 10 Pound Sterling * Photocopy: 100 pages @ 5 pence= 5 Pound Sterling 10. Time-Plan: Time plan for the literature review is provided below: September 2007: Start October 2007: Search for literatures December 2007: Review the literatures January 2008: Analysis March 2008: Start writing the report June 2008: Submission of report 11. ...read more.

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