Strageties for prevention of disease

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9.4  Strategies for prevention of disease

There are many strategies working to reduce the risk of developing a disease. These include national, local and personal lifestyle strategies. These strategies depend on whether the diseases are communicable or non-communicable. The body can protect itself through its natural defences; no-specific mechanisms and the immune system. Infection influenza occurs if an infecting virus gets past the bodies defence or the defences break down.

Prevention of lung cancer includes quitting smoking and avoiding exposure to potentially cancer-causing substances in the work environment. The best way to prevent lung cancer is not to smoke or to quit smoking if one has already started. Educational efforts, aggressive public health campaigns, anti-tobacco legislation, over-the-counter nicotine replacement therapies combined with specific antidepressants (eg, Zyban), and intense social pressures that “denormalise” smoking are helping smokers to quit. Second-hand smoke from other people's tobacco should also be avoided.

Eat well-balanced meals. Diets rich in fresh fruits and vegetables may be protective against lung cancer in both smokers and non-smokers. In any case, diets with plenty of fresh fruits and vegetables are rich not only in important vitamins but also in other beneficial nutrients called phytochemicals (phyto simply means plant) that are necessary for all aspects of health. Important cancer-fighting phytochemicals include isothiocyanates found in the cruciferous vegetables (eg, broccoli, cauliflower, and Brussels sprouts), flavonoids (major sources are apples, grapefruit, onions, red wine, and tea), soy protein, and lycopene. Diets high in animal fats increase the risk for lung cancer. Others have suggested some protection from cod liver oil, which contains omega-3 fatty acids (found in fatty fish), omega-6 fatty acids (found in flax and soybean and canola oil), and monounsaturated oils (found in olive and canola oils). Despite these interesting pieces of information, the ability of these substances to protect against lung cancer remains controversial, and discontinuation of smoking remains the best advice. Some B vitamins are being considered as cancer fighters. Folic acid and B12 convert the amino acid homocysteine to methionine, which in turn protects genes that help prevent malignancies in cells. Vitamin A and nutrients called carotenes (some of which convert to vitamin A) have been researched for possible protection against lung cancer. Selenium appears to inhibit cell proliferation and may have other anti-carcinogenic properties.

Test houses for the presence of radon gas, and removing asbestos from buildings are also useful preventive strategies. People concerned about radon in their home or area can purchase a test approved by the Environmental Protection Agency. Methods for removing radon include installing a soil suction system. It should be noted, however, that home prevention measures rarely reduce radon levels to zero. Simply sleeping by an open window reduces the risk.

Lung cancer screening refers to strategies used to identify early lung cancers before they cause symptoms, at a point where they are more likely to be curable. Screening refers to the use of medical tests to detect disease in people not showing or producing indications of a disease or other medical condition. Possible screening tests for lung cancer include chest radiograph or computed tomography (CT) of the chest. So far, screening programs for lung cancer have not demonstrated any clear benefit. Randomised controlled trials are underway in this are to see if decreased long-term mortality can be directly observed from CT screening.

Screening studies have only been done in high risk populations, such as smokers and workers with occupational exposure to certain substances. This is because radiation exposure from repeated screening studies could actually cause cancer formation in a small percentage of screened subjects, so this risk should be reduced by a (relatively) high prevalence of lung cancer in the population being screened.

The preferred treatment for influenza, and consequently most viral infections is prevention. This prevention can be achieved through vaccinations. Influenza vaccinations are given to millions annually. The vaccine is actually a trivalent vaccine meaning that one injection contains three subtypes. People who are at a high risk of infection with influenza, or are more likely to get complications if infected, should get vaccinated against the disease every year. Each year’s flu vaccine is different because it is adjusted to combat whatever virus strains are expected to be circulating that season. There is growing support for a policy of recommending the influenza vaccine to all adults, and many doctors will give the vaccine to any adult who requests it.

Several antiviral drugs can be used to prevent infection with influenza virus. Doctors may prescribe these drugs when a person has a clear, recent exposure to someone with influenza. In addition, these drugs are used during epidemics of influenza to protect unvaccinated people who are at high risk of complications of influenza: older people and people with chronic illnesses. Amantadine and rimantadine are older antiviral drugs that offer protection against influenza type A but not influenza type B. Two new drugs, oseltamivir and zanamivir, can prevent infection with either influenza virus type A or type B. These drugs produce minimal side effects.

The influenza virus usually is passed through the air, by coughing and by direct contact, such as shaking hands or kissing. For this reason, practicing good hygiene - covering your mouth when you cough and washing your hands frequently - can help you to avoid getting the flu or spreading it to others.

Vaccination is the principle measure for preventing influenza and reducing the impact of epidemics. Various types of influenza vaccines have been available and used for more than 60 years. They are safe and effective in preventing both mild and severe outcomes of influenza. The vaccine is made by purifying proteins from three different strains of the influenza virus. Because influenza viruses are continuously mutating to avoid our immune systems, new vaccines are made up every year. To remain protected from the influenza virus you need the new vaccine each year. Protection develops about 2 weeks after receiving the vaccine. All current inactivated influenza vaccines contain trace levels of egg protein and should not be used by individuals with egg protein allergies.

Each season's flu vaccine contains three virus strains that are the most likely to be encountered in the coming flu season. When there is a good match between the anticipated flu strains and the strains used in the vaccine, the vaccine is 70-90% effective in people under 65. Because immune response diminishes somewhat with age, people over 65 may not receive the same level of protection from the vaccine, but even if they do contract the flu, the vaccine diminishes the severity and helps prevent complications. The virus strains used to make the vaccine are inactivated and will not cause the flu.

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It is recommended that elderly persons, and persons of any age who are considered at “high risk” for influenza-related complications due to underlying health conditions, should be vaccinated. Among the elderly, vaccination is thought to reduce influenza-related morbidity by 60% and influenza-related mortality by 70-80%. Among healthy adults the vaccine is very effective (70-90%) in terms of reducing influenza morbidity, and vaccination has been shown to have substantial health-related and economic benefits in this age group. The effectiveness of influenza vaccine depends primarily on the age and the ability of the body to develop an immunity response in the ...

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