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This assignment will describe the pathogenesis and clinical feature of clostridium difficile infection and will discuss how the bacteria virulence factors and allow it to infect humans.

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Introduction

Clostridium Difficile This assignment will describe the pathogenesis and clinical feature of clostridium difficile infection and will discuss how the bacteria virulence factors and allow it to infect humans. Clostridium difficile is an anaerobic gram-positive, this type of bacteria have a very think outer cell layer and have different layer form the outside of their cells. Clostridium difficile is transmitted trough the fecal oral route. However the best and most important virulence factors are the clostridium difficile erotoxin. Erotoxin can cause damage to the host by destroying cells or disrupting normal cellular metabolism. Clostridium difficile is now recognise is the chief causes of hospital acquired diarrhoea in the UK and not only in the hospital but in nursing home another facility for long care. This bacterium was first discovered was difficult to grow in the laboratory, is a bacterium of the Clostridium family (Department of Health, UK 2007). ...read more.

Middle

Other people may get this bacterium through the spores, since spores can survive on the air or on the surface. Too many clostridium difficile can be harmful. The main cause for clostridium difficile to increase is caused by antibiotics. When a person is taken antibiotics, some antibiotics kill other harmless bacterium. When this is happening it causes clostridium difficile to increase rapidly and produce toxins. There are two toxins that normally required and causing clostridium difficile diarrhoea. Toxins A and B, toxin A is play more critical than toxin B in the pathogenesis of clostridium difficile diarrhoea. Because is the only way it is associated with the content tissue damage. Toxin B has no notice direct when enters toxin and play a role only after the gastro intestinal wall gastrointestinal has been damage by toxin A. Toxin A is a negative don't essential for virulence. ...read more.

Conclusion

We must remember that infection control is paramount and it is everyone's responsibility. Evaluation It took me quite a long time to start this assignment, mainly because l was trying to search more information about the bacteria and understanding more before writing down. I did a lot research and mainly realised that l had too much information and l had to compromise what to use. Writing the essay has made me understand more about clostridium difficile. It was a bit stressful for me to start writing the assignment, but finally I am pleased with the work I have done, and hope to improve with my subsequent assignment. Reference Dr, Kenny, B. (2009) Pharmacy Informatics Team (Online) Available from: http://www.patient.co.uk/about.asp#jd1 (Access on 23/03/2010). Dr. Donal O'Donoghue (2007) clostridium difficile infiction. (Online) Available from: http://www.wellsphere.com/detailedSearch.s?keyword=clostridium+difficile+infections (Access on 31/07/ 2009). Health. Protection. Agency (2010) clostridium difficile infection (online) Available from http://www.hpa.org.uk/Topics/InfectiousDiseases/InfectionsAZ/ClostridiumDifficile/ContactDetails/ (Access on 03/11/2010). David. N. (2007) Infection and update on clostridium difficile. (Online) Available from: http://www.dh.gov.uk/prod_consum_dh/groups/dh_digitalassets/@dh/@en/documents/digitalasset/dh_076984.pdf (Access on 25/07/2007). ?? ?? ?? ?? 1 ...read more.

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Here's what a teacher thought of this essay

4 star(s)

This is a good attempt to write about a disease. It is a bit muddled in places and I feel that the writer has not fully understood the disease but it is difficult to write about unless you are a biologist at heart.

To enhance the essay, more discussion could be given to why people in hospitals might be more susceptible and exactly what C.Diff does to you.

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Marked by teacher Sam Morran 13/08/2013

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