Explain what HLA groups are, and their significance.

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Explain what HLA groups are, and their significance.

HLA stands for Human Leukocyte Antigen and is found on white blood cells, more specifically on chromosome 6. The HLA- group of an individual is determined by a combination of the three genes of the HLA- system, called A, B and C.

Each loci on the antigen have a large number of alleles, which means that it is a huge number of combinations. There are more precisely 9,5 million different ways of which they can recombinate. HLA- A has 20 combinations, B has 40 and C has 20. It is extremely rare to find two people with the same combinations. One can say that the significance of the HLA- groups is to predict if a transplant will work or not. This is not easy because of the variety. The importance is to find the ‘best match’.

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What is meant by the “genetic lotto”?

The “ genetic lotto” is a constructed model that is used to illustrate the possible connections between HLA- A, B and C, ABO blood types, and rhesus positive and rhesus negative. There are approximately 2 million combinations.

What factors limited the number of children born to a woman before the advent of modern contraceptive technology?

A woman’s biological capacity is to give birth to 15 children but this is quite rare. 6-7 children are more common. In addition to the biological limitations there are mentioned three different factors at the exhibition. ...

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