The roll of stress in the development of ulcers.

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2/10/02

The roll of stress in the development of ulcers

Brady study (1958)

  • Brady linked high levels of stress to increased hormone production and the development of ulcers (Perforated ulcer).
  • Placed a monkey in a restraining chair and taught them to press a lever.
  • They had an electric shock every 20 seconds unless they pressed the lever within that time.
  • There were 2 levels of stress:
  • Physical stress – from getting the shock
  • Psychological stress – from having to press the lever
  • The experiment came to a halt when all his monkeys died, he found out they all died of ulcers and had high levels of gastro intestinal hormone

  • He had to test what gave the monkeys the ulcers
  • Next they used 2 monkeys in separated chairs
  • 1 was the executive monkey that had control of the shocking as it had the lever, if he pressed the lever within the 20 seconds, and then none of the monkeys got the shock.
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  • Only the executive monkey suffered from psychological stress as it had the lever to deal with
  • After 23 day’s. 6 hours on, 6 hours off, they died of a perforated ulcer
  • He tried various other routines such as different time intervals, but no other monkeys died, and the acidity of the stomach was no way as high.
  • The acidity of the stomach was the highest during the period off.
  • When kick backs of stress starts, there is a high level of parasympathetic hormones and there is an overload of this.

Evaluation

  • Confirmed that ulcers were related to stress
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