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Analysis of neutralizing power of anti-acid tablets

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Introduction

Analysis of neutralizing power of anti-acid tablets By: 6A Ting Ting Chang (1) Katie Cheung (2) Winnie Yeung (27) Chemical Principles: Neutralization occurs when acid and alkali are mixed together. It involves the reaction between H+ and OH-, forming salt and water. The properties of acid and alkali will be cancelled out in the process of neutralization. In our stomach, the gastric juice inside contains concentrated HCl (at about pH2). When excessive amount of gastric juice is secreted, we will feel discomfort in stomach or even heartburn. In this case, anti-acid tablets can be used to relief the pain. The suspension of the anti-acid contain OH- which will combine with the H+ found in the HCl of the juice to form a salt and water. Thus, the excess gastric juice can be neutralized. In this experiment, the active ingredient contents (Mg(OH)2 / Al(OH)3) of different brands of anti-acids are analyzed using volumetric analysis. ...read more.

Middle

Fedra-Gel-S Contents: Aluminium Hydroxide Dried Gel 200mg Magnesium Hydroxide 200mg Simethicone 30mg * Simethicone is an anti-foaming agent that decreases the surface tension of gas bubbles, causing them to form larger bubbles in the stomach that can pass through the oesophagus easily by burping. Some calculations involved before designing the experiment: No of mol of OH- in one tablet: 0.2x3 + 0.2x2 26.98+(16.0+1.0)x3 24.3+(16.0+1.0)x2 = 0.014555 No of mol of H+ required: 0.014555 No of mol of HCl required: 0.014555 Since No of mol= Molarity x Volume, Volume of HCl: No of mol Molarity = 0.014555 1 = 0.014555 dm3 = 14.6 cm3 ? The minimum amount of 1M HCl required to dissolve all the OH- inside one anti-acid tablet is 14.6 cm3. ? The 0.1 M NaOH used should be in the range of 15 - 40 cm3. Let x be the added amount of 1M HCl. (x-0.0146) � 1 � 10 � 250 = 0.040 � 0.1 x = 0.1146 ? ...read more.

Conclusion

With the use of the filter funnel, rinse the burette with distilled water and then with 0.1M NaOH. 8. Fill the burette with 0.1M NaOH. Record the initial reading of the burette. 9. Add a few drops of phenolphthalein into the conical flask. 10. Run the 0.1M NaOH into the conical flask until the solution turns from colourless to permanent pink. 11. Record the final reading of the burette. 12. Repeat the above steps several times to obtain a mean titre. 13. Repeat the whole process by using different brands of anti-acid tablets. Calculations: Mean titre of NaOH used: V1 No of mol of OH- used: V1 � Molarity (0.1M) = 0.1V1 No of mol of H+ used to react with OH-: 0.1V1 No of mol of H+ left after the neutralization with the anti-acid tablet: 0.1V1 � 250 � 10 = 2.5 V1 No of mol of H+ used by the anti-acid tablet: Total no of mol of HCl used -2.5 V1 = 100 -2.5 V1 No of mol of OH- in each anti-acid = No of mol of H+ used = 100 -2.5 V1 ?? ?? ?? ?? 1 ...read more.

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