• Join over 1.2 million students every month
  • Accelerate your learning by 29%
  • Unlimited access from just £6.99 per month

Can Germ line Gene Therapy be used as a treatment for Huntingtons Disease?

Extracts from this document...

Introduction

Can Germ line Gene Therapy be used as a treatment for Huntington's Disease? Target Audience: Biology A-Level Graduates Report Outline Gene Therapy has been used to reduce the effects of many diseases, but so far, very few solutions have arisen for Huntington's disease. I will be exploring the effectiveness of germ line therapy compared to its risks and morality. Problem Huntington's disease is a genetic condition where there is a mutation in the DNA sequence on the dominant gene 'huntingtin'. The mutation is repetitive so there is more than just one chromosome effected by this mutation. This means the offspring of a Huntington's disease carrier has a 50% chance of developing the disease. Huntington's disease is a neurodegenerative genetic disorder which means the neurones in the brain can lead to a cognitive decline over time. Because this process takes years before it shows any signs of effect, most people don't realize they have Huntington's disease until they reach mid-life. The gene 'huntingtin' codes for the Huntington protein, commonly found around areas of the brain. When a mutation occurs, this protein is no longer produced and instead a different form of protein is produced. ...read more.

Middle

They found that providing new genetic instructions which counteracted the production of the mutated protein and a supplement of Huntington's protein, lowered the effects of the disease on mice. "Gene therapy in these models successfully attenuated the symptoms of Huntington's disease and increased life span." (2) Benjamin F. Biaggini, Professor of Biological Sciences. Benefits and Risks One of the most important questions to take into consideration is whether the 'benefits outweigh the risks'. Gene therapy has a wide variety of balanced benefits and risks. This is what makes it such a controversial subject. The main benefit of gene therapy is that it can effectively reduce the symptoms of diseases, diseases such as Huntington's Disease, cystic fibrosis, sickle cell anaemia and many others. This could be a massive medical breakthrough Another benefit is that if germ-line therapy research is continued, we could be able to completely wipe out diseases by removing the gene before it starts to replicate. This is similar to stem cell research as it is working with early embryos to eradicate the disease before it is too late. However, gene therapy is not 100% safe especially with the stage it is at now. ...read more.

Conclusion

Alternatives There are also many effective alternatives to gene therapy which are arguably more cost-effective than gene therapy. Perhaps one of the most popular alternatives is stem cell research. This research has been competing with gene therapy for cures to diseases since the 90's. Stem cell research offers the chance to create a clone of a human being which does not have Huntington's disease. This also has a lot more research needed to be done before it is deemed acceptable by society. Another alternative is drug therapy. This therapy is already being used by most patients suffering from Huntington's disease. Drugs are very cost efficient and simple, but concern has arisen over the effectiveness on patients and these drugs cannot fully eradicate the symptoms of Huntington's disease. Physiotherapy is a kind of treatment that also seems to have good effects on patients. Sufferers can take part in mental and physical exercises which have proven to delay the effects of Huntington's disease. In my opinion, Gene therapy remains the most important way of treating Huntington's disease, although it may require more study and analysis, the future of gene therapy for cures looks promising, and with more finance being invested in research, this could be a medical breakthrough for many genetic diseases. ...read more.

The above preview is unformatted text

This student written piece of work is one of many that can be found in our AS and A Level Genetics, Evolution & Biodiversity section.

Found what you're looking for?

  • Start learning 29% faster today
  • 150,000+ documents available
  • Just £6.99 a month

Here's what a teacher thought of this essay

3 star(s)

***
A sound outline of the arguments surrounding the use of gene therapy but lacking in some detail of the technical processes, and of sociological debates surrounding the issue.

Marked by teacher Jacqui Punter 21/02/2012

Not the one? Search for your essay title...
  • Join over 1.2 million students every month
  • Accelerate your learning by 29%
  • Unlimited access from just £6.99 per month

See related essaysSee related essays

Related AS and A Level Genetics, Evolution & Biodiversity essays

  1. Marked by a teacher

    Pros and Cons of Genetic Engineering

    4 star(s)

    The basis of gene therapy is to supply a functional gene to cells lacking that particular function, thus correcting the genetic disorder or disease. There are two main categories of gene therapy: germ line therapy, or altering of sperm and egg cells, and somatic cell therapy, which is much like an organ transplant.

  2. Marked by a teacher

    Understanding DNA Coursework

    4 star(s)

    This is called a phosphodiester bond. This reaction applies to both RNA and DNA. However DNA consists of a double helix, therefore, two polynucleotides strands. In this case the two polynucleotide strands face each other side by side, and are held together by hydrogen bonds between the nitrogen containing bases (see diagram below).

  1. Marked by a teacher

    The problem of low genetic diversity in cheetahs and its effects on conservation.

    Why low genetic diversity a problem and the affects it has on Cheetahs. The Cheetah, a member of the cat family but is a bit of an outcast because will choose to run rather than fight If attacked which means it cannot fight to protect its food or it's young.

  2. Marked by a teacher

    'Discuss the advantages and disadvantages of the use of gene technology.'

    Scientists have kept full copies of the DNA of animals such as rhinoceroses, tigers and condors so that maybe one day clones may be brought to life. There is an example of a clone of an animal, Dolly the sheep.

  1. Biology Report - Effect of Environment on Phenotype

    Place the cups into four grouped rows and then assign each of the cups from each pH group a number from 1-4, again labeling with the marker pen. 2. Fill 5 1L water jugs with 800mL of distilled water and label the jugs; 6.4, 6.6, Neutral, 7.4 and 7.6.

  2. microbiology ph and temperature effect on bacterial culture

    5 N/a N/a N/a N/a Absorbance group 6 0.01 0.55 0.31 0.01 Absorbance group 7 0.04 0.01 0.49 0.01 Absorbance Group 8 N/a N/a N/a N/a Absorbance Group 8 0.06 0.64 0.01 0 Absorbance Group 9 N/a N/a N/a N/a Mean 0.03 0.45 0.37 0.01 The mean of each micrococcus

  1. Edexcel Level 3 Extended Project - Should Embyonic Stem Cell Research be applied to ...

    The opposition is mainly religious groups while the support is mainly scientists, but of course there are exceptions. Some people may not have any religious beliefs but still have strong views on morality, and some people may not be scientists, or in fact have any scientific knowledge, but have different beliefs about the moral status of a human embryo.

  2. The Production of Vaccines using Genetic Engineering.

    Secondly genetic engineering, genetic engineering is the process of taking genes and segments of DNA from one species and putting them into another species, thus breaking the species barrier and artificially modifying the DNA of various species. These changes in the DNA result in an alternation of reproductive and

  • Over 160,000 pieces
    of student written work
  • Annotated by
    experienced teachers
  • Ideas and feedback to
    improve your own work