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Haemophilia is a bleeding disorder whereby blood doesnt clot properly.

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Introduction

Haemophilia Haemophilia is a bleeding disorder whereby blood doesn't clot properly. It is caused by not having enough of one of the essential clotting ingredients (called factors) in the blood. Haemophilia A, or Classical Haemophilia, is the most common form and is due to the deficiency of factor VIII. Haemophilia B is due to factor IX deficiency. Haemophilia A is five times more common than haemophilia B1. For blood to clot normally, a person needs to have at least thirty percent of the clotting factor. ...read more.

Middle

Haemophilia is caused be a sex-linked recessive gene therefore in order for it to be expressed in the phenotype it must be homozygous. Every person has two sex chromosomes. Women have two X-chromosomes while a man has one X and one Y chromosome. Both factor VIII and IX proteins are located on the X chromosome. A fault in the Factor VIII or IX gene on the X chromosome will result in Haemophilia A or B. ...read more.

Conclusion

Although females only rarely have symptoms of the disorder, they may carry the haemophilia gene and may pass on the disorder to their sons. Sons of women with the haemophilia gene have a one in two chance of being affected and daughters will have a one in two chance of carrying the haemophilia gene. Though there is no cure for haemophilia, it can be controlled with regular injections of the deficient clotting factor, i.e. factor VIII in haemophilia A or factor IX in haemophilia B. Some haemophiliacs develop antibodies (inhibitors) against the replacement factors given to them, so the amount of the factor has to be increased or non-human replacement products must be given. ...read more.

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