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Preparation of Antifebrin

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Introduction

Preparation of Antifebrin Safety of Chemicals Phenylammonium Chloride (C6H5NH3Cl) * Highly Toxic * Carcinogen (can cause cancer) * Irritant to eyes and skin * Harmful if inhaled, swallowed or touched Sodium Ethanoate (CH3COONa) * May be harmful to skin * Moderately toxic by ingestion * Irritant to skin and eye Ethanoic Anhydride ((CH3CO)20) * Corrosive * Harmful if swallowed * Contact to eyes may cause irritation or burns Antifebrin (CH3CONHC6H5) * Irritant * Can cause a weak pulse and faintness if too much is inhaled or swallowed Safety precautions * Goggles will be worn throughout the experiment. This will protect my eyes against splashes of chemicals * Safety gloves will also be worn throughout the experiment; this will protect my hands from the chemicals so it does not harm/damage my skin. * A lab coat will be worn to protect my clothes and skin from the chemicals used. * All glassware and containers will be moved into the middle of the table. This will ensure that they are not knocked of the table to cause a hazard. These containers will also be tightly sealed if not in use. * I will use ethanoic anhydride in a chemical fume cupboard. ...read more.

Middle

Recrystallise The crude sample of antifebrin needed to be recrystallised in step 5. To begin the sample was dissolved in a small amount of hot water so that that sample became saturated. After a couple minutes the solution was then allowed to cool in a bowl of ice, in which solid crystals formed. The solid crystals were then separated under reduced pressure, using the method described above. Readings recorded To ensure each reactant had a high degree of accuracy I repeated each measurement three times. When using the scales to measure reactants such as sodium ethanoate, I placed a small glass dish on the scales, and recalibrated the scales so that the weight of the dish was not included. After each weighing I wiped off and recalibrated the scales to make sure no small substances would disrupt the next reading. Phenylammonium chloride 1.0g of Phenylammonium chloride was needed to dissolve into water. This was done by placing a dish on the scales and carefully added small amounts of phenylammonium chloride using a spoon. I repeated this three times, while recalibrating the scales after each weighing. The readings are as follows: Reading 1/g Reading 2/g Reading 3/g 1.0 1.01 1.0 The mass of Phenylammonium chloride was therefore 1.0g, because only 2 significant figures were required. ...read more.

Conclusion

I dried off the antifebrin by dapping it with filter paper. To measure the melting point required a small amount of dried Antifebrin, which was collected in a capillary tube. The tube required only a small amount which was tapped to allow the substance to settle at the bottom. The tube was feed into the electronic equipment, which would heat up to melt the substances in the tube therefore finding out the melting point. I was able to view the substances in the tube from the top of the equipment, to see we it had melted into a liquid. However it was difficult to pin point an exact melting point, the temperature at which the substance melted lie between 116oC - 118oC. Percentage Yield To find out the percentage yield the following formula will be used: Actual mass / Expected mass x 100 Step 1: Find the moles of Phenylammonium chloride Mass used in experiment = 1.0 Molar mass = 129.5 Number of mole = mass (1.0) / Mr (129.5) = 7.722 x10-3 Step 2: Find the mass of Antifebrin Molar mass of Antifebrin = 135 Mass = moles (7.722 x10-3) x molar mass (135) = 1.042 (3.dp) Step 4: Find the Percentage Yield Percentage yield = actual mass / expected mass x100 = (0.44 / 1.042) x 100 = 42. 23 (2.dp) The percentage yield of this experiment is 42%. ?? ?? ?? ?? ...read more.

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