Preparation of Antifebrin

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Preparation of Antifebrin

Safety of Chemicals

Phenylammonium Chloride (C6H5NH3Cl)

  • Highly Toxic
  • Carcinogen (can cause cancer)
  • Irritant to eyes and skin
  • Harmful if inhaled, swallowed or touched

Sodium Ethanoate (CH3COONa)

  • May be harmful to skin
  • Moderately toxic by ingestion
  • Irritant to skin and eye

Ethanoic Anhydride ((CH3CO)20)

  • Corrosive
  • Harmful if swallowed
  • Contact to eyes may cause irritation or burns

Antifebrin (CH3CONHC6H5)

  • Irritant
  • Can cause a weak pulse and faintness if too much is inhaled or swallowed

Safety precautions

  • Goggles will be worn throughout the experiment. This will protect my eyes against splashes of chemicals
  • Safety gloves will also be worn throughout the experiment; this will protect my hands from the chemicals so it does not harm/damage my skin.
  • A lab coat will be worn to protect my clothes and skin from the chemicals used.
  • All glassware and containers will be moved into the middle of the table. This will ensure that they are not knocked of the table to cause a hazard. These containers will also be tightly sealed if not in use.
  • I will use ethanoic anhydride in a chemical fume cupboard.
  • While conducting my experiment I will keep all my equipment in my area and not take up to much space so that my neighbour can have enough space to conduct their experiment.
  • When my experiment is finished I will wash my hand thoroughly with hand wash.

Observation

  1.  First step was to dissolve 1.0g of phenylammonium chloride in 30cm3 of water. The phenylammonium chloride dissolved completely in the water, producing a fairly clear solution.
  2.  Second step was to prepare a solution of 6.0g of sodium ethanoate in 25cm3 of water. The sodium ethanoate dissolved in the water leaving a few undissolved granules at the bottom of the flask. The solution was left fairly clear.
  3.  Third step was to add 2cm3 of ethanoic anhydride to the solution of phenylammonium chloride. Before I began stirring a small solid formed, but as I started stirring it slowly dissolved leaving no precipitate and a clear solution.
  4.  Sodium ethanoate was added to the ethanoic anhydride and phenylammonium chloride solution. A white cloudy precipitate immediately formed, as I stirred the solution a thick solution with a lot of white/grey precipitate formed.
  5.  The precipitate formed was purified by filtering it under reduced pressure in a Buchner flask. This produce a white, shiny crystals, which however was still wet. Once dried the product became a dry powder form, crystalline.
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Filtering

The product formed from the addition of ethanoic anhydride and solution phenylammonium chloride, needed to be filtered under reduced pressure and then washed with a little cold water. To filter the product a Buchner flask was used, the buchner funnel was attached to the flask and the other end to a fully flowing cold tap. As the tap was left running, the pressure in the flask was reduced. The pressure produced sucked the liquid in the , through to the conical flask below. In the hose barb was just the solid crystals.

Recrystallise

The crude sample ...

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