Preparation of Antifebrin
Safety of Chemicals
Phenylammonium Chloride (C6H5NH3Cl)
- Highly Toxic
- Carcinogen (can cause cancer)
- Irritant to eyes and skin
- Harmful if inhaled, swallowed or touched
Sodium Ethanoate (CH3COONa)
- May be harmful to skin
- Moderately toxic by ingestion
- Irritant to skin and eye
Ethanoic Anhydride ((CH3CO)20)
- Corrosive
- Harmful if swallowed
- Contact to eyes may cause irritation or burns
Antifebrin (CH3CONHC6H5)
- Irritant
- Can cause a weak pulse and faintness if too much is inhaled or swallowed
Safety precautions
- Goggles will be worn throughout the experiment. This will protect my eyes against splashes of chemicals
- Safety gloves will also be worn throughout the experiment; this will protect my hands from the chemicals so it does not harm/damage my skin.
- A lab coat will be worn to protect my clothes and skin from the chemicals used.
- All glassware and containers will be moved into the middle of the table. This will ensure that they are not knocked of the table to cause a hazard. These containers will also be tightly sealed if not in use.
- I will use ethanoic anhydride in a chemical fume cupboard.
- While conducting my experiment I will keep all my equipment in my area and not take up to much space so that my neighbour can have enough space to conduct their experiment.
- When my experiment is finished I will wash my hand thoroughly with hand wash.
Observation
- First step was to dissolve 1.0g of phenylammonium chloride in 30cm3 of water. The phenylammonium chloride dissolved completely in the water, producing a fairly clear solution.
- Second step was to prepare a solution of 6.0g of sodium ethanoate in 25cm3 of water. The sodium ethanoate dissolved in the water leaving a few undissolved granules at the bottom of the flask. The solution was left fairly clear.
- Third step was to add 2cm3 of ethanoic anhydride to the solution of phenylammonium chloride. Before I began stirring a small solid formed, but as I started stirring it slowly dissolved leaving no precipitate and a clear solution.
- Sodium ethanoate was added to the ethanoic anhydride and phenylammonium chloride solution. A white cloudy precipitate immediately formed, as I stirred the solution a thick solution with a lot of white/grey precipitate formed.
- The precipitate formed was purified by filtering it under reduced pressure in a Buchner flask. This produce a white, shiny crystals, which however was still wet. Once dried the product became a dry powder form, crystalline.