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Preperation of Antifebrin

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Introduction

Preparation of Antifebrin In this experiment, I am going to prepare the organic compound of antifebrin from readily available chemical reagents. Antifebrin is an odourless solid chemical of white flake-like appearance. Chemically, antifebrin is the amide phenylethanamide CH3ONHC6H5. It's slightly soluble in water. It does have the ability to self-ignite if it reaches the temperatures of 545�c but otherwise it's a stable compound. The pure crystals of antifebrin are plate shaped and white in colour. The antifebrin in this experiment is prepared from the reaction between phenylammonium chloride (C6H5NH3Cl) and ethanoic anhydride[ (CH3CO)2O ]. Chemical Equation for the Reaction: C6H5NH3+ Cl- + (CH3CO)2O CH3ONHC6H5 + CH3OOH + HCl Procedure & Observations: Procedure Observation Dissolve 1.0g of phenylammonium chloride in 30cm3 of water in a conical flask. Phenylammonium chloride is a greyish-green crystal like product. Adding water to it gives a solution pale grey with green tinge. ...read more.

Middle

Recrystallise the whole product from the minimum volume of hot water. As it boils the crystals dissolve but the impure black blobs appear. Adding little more water and boiling dissolves these impurities and leaves a colourless solution. Then allow the mixture to cool and when crystallisation, it would give a compound of pure product, more pure and larger precipitate is formed. Filter off the pure product again under reduce pressure. This results in another wet sample but it is purer and has bigger and whiter wet crystals. After filtering, dry the bulk of the product in air and small portion between filter paper After drying, the final products are dry sparkling white sharp needle like crystals. Measurements and Results: Mass of phenylammonium chloride used = 1.000g Mass of sodium ethanoate used = 6.012g Melting Points: Rough 1st Accurate 2nd Accurate 3rd Accurate Mean Melting Point 112�c 114�c 114�c 113�c 114�c Yield: C6H5NH3+ Cl- + (CH3CO)2O CH3ONHC6H5 + CH3OOH + HCl Mr of phenylammonium chloride ...read more.

Conclusion

* Always keep the bottles of chemicals closed with tops if not being used. * Phenylammonium chloride is harmful if absorbed through the skin and maybe harmful if inhaled or swallowed. * Sodium ethanoate maybe harmful if large amount is swallowed. If there's an eye or skin contact, rinse immediately with water and if irritation persists, ask for medical help. * Ethanoic anhydride is strongly corrosive and can cause serious burns. It is poisonous and will cause serious damage if swallowed or inhaled. Do not allow the pure liquid or a solution containing it to come into contact with your skin. Ensure that you work only in an area with good ventilation - do not breathe the fumes. If there's an eye contact, immediately rinse your eyes with water for 10 minutes and call for medical help. If there's a skin contact, wash the skin with plenty of water, remove any contaminating clothing and call for medical help. If swallowed, immediately seek medical help. ?? ?? ?? ?? Hassan Tahir ...read more.

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Response to the question

The candidate carries out the experiment well. They show how the material would be prepared, and work out the calculations correctly to make the substance. Observations are recorded to a high level of detail. To improve the candidate should provide ...

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Response to the question

The candidate carries out the experiment well. They show how the material would be prepared, and work out the calculations correctly to make the substance. Observations are recorded to a high level of detail. To improve the candidate should provide a conclusion and an evaluation based on the yield of the experiment and how the experiment went to point out errors and improvements to the experiment. This shows a deeper understanding of the experiment.

Level of analysis

For the candidate to expand on the experiment and show wider scientific significance they should state the uses of the substance in society. Chemical equation uses correct notation. The candidate presents the method in a very clear way with the procedure written in a table with the observations next to it, which is a brilliant way as it shows us how the experiment progresses as well as communicating in an easy to decipher way. Calculations are correct but decimal places lack consistency and shouldn't to make calculations accurate. Safety precautions are considered which is also good.

Quality of writing

The format is done very well with easy to read tables and information. Grammar, punctuation, and spelling are all to a high standard.


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