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Research project. Type 1 diabetes, is there a solution?

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´╗┐The biological problem of Diabetes type 1, is there a definite cure to it? The Problem Since 1996 the number of people diagnosed with diabetes type 1 has been increasing rapidly up until this current year of 2012 from 1.4 to 2.9 million, and as said by most health experts that these figures would continue to increase to such as 5 million by 2025. This is becoming an increasing biological issue as this inherited disease can lead to one prone to a chain of more failures within the body and result to the fatal outcome of death. The statistics below help to identify and confirm as to why diabetes type 1 is one of the most major health problems being faced within places especially in the UK. http://www.diabetes.org.uk/Documents/Reports/Diabetes-in-the-UK-2012.pdf From the table above we can see how largely the disease of diabetes type 1 has spread last year within the United Kingdom especially in England where the figures had exceeded over 2 million people. As well as the statistics from the table it is also known that there were more than 850,000 people who had diabetes that we not diagnosed, also alongside adults children are increasingly becoming affected by diabetes type 1. As currently it is approximated that one child per 700 to 1000 is known to have been affected by type 1 diabetes, and that primary trust care expects 100 to 150 children with type 1diabetes in most areas. Health experts have also identified that the peak age when children catch onto type 1 diabetes is within the years 10 to 14. Why is this problem? ...read more.


http://www.aafp.org/afp/1998/0115/p279.html http://www.aafp.org/afp/1998/0115/p279.html From this we graph we can see that insulin Lispro begins to exert its effects within 15 minutes of administration, patients must eat within this time period. Compared with insulin Lispro, regular human insulin has a slower onset of action. Insulin peaks in about 3 hours and continues to work for about 4 more hours. From this we can understand why its dosages are to be taken in short time period before and after meal intakes. This woulb be useful and effective for someone with diabetes as it means there would be a faster rate in the control of blood glucose levels Solution 2 Long-Acting (Ultralente) Insulin: Long-acting insulin, such as insulin glargine (Lantus), is released slowly. Insulin glargine matches parts of natural human insulin and maintains stable activity for more than 24 hours. Insulin glargine differs from human insulin by the substitution of glycine for alanine at position 21 of the insulin A-chain plus the addition of two extra amino acids ? both arginines ? at the end of the insulin B-chain, extending it from its usual length of 30 amino acids to 32 amino acids. This is the reason why its activity is prolonged than normal human insulin. http://www.endotext.org/diabetes/diabetes17/diabetesframe17.htm The graph below demonstrates the activity of insulin glargine in comparison to other types of insulin: http://dtc.ucsf.edu/types-of-diabetes/type2/treatment-of-type-2-diabetes/medications-and-therapies/type-2-insulin-rx/types-of-insulin/ From this we can see how it peaks around 5 hours after injection and continues in a long and consistent glucose infusion rate up until 20 hours where it starts to fall in its rate. Implications of Solutions: Both the insulin are useful for their outcomes and its purpose Insulin Lispro allows rapid action which reduces the risk for hypoglycaemic events after eating (postprandial hypoglycaemia) ...read more.


This means the drug isn?t a very common drug as it has only been approved recently so patients maybe quite unsure to use it as a treatment, but also as the drug has more side effects in comparison to insulin, so it wouldn?t be the safest choice of a treatment. http://www.umm.edu/patiented/articles/what_insulin_how_it_used_treat_diabetes_000009_8.htm Conclusion: Thousands of patients including both children and adults are diagnosed with type 1 diabetes all over the countries including both more economically developed countries such as Britain and the U.S.A to less economically developed countries such as India and Bangladesh, out of which most experiencing the severe problems of the diseases even the most fatal outcome of death. There are several treatments for this disease ranging from treatments such as insulin that has been available since the very beginning of the diseases up until new formed drugs such as Pramlintide (Symlin), however alongside the fact that either the treatments aren?t very cost- effective e.g. insulin pumps or isn?t the most effective or safest such as Pramlintide (Symlin); there hasn?t been a treatment that completely stops type 1 diabetes from occurring or cures it after the patient becomes affected by it. All the treatment mentioned above only help to regulate blood sugar levels, by improving the resistance and control of insulin within the body for a type 1 diabetes patient or helps to reduce the chances of major fatal outcomes and complications that the disease can lead to. Therefore although there are treatments currently available which effectively treats diabetes and helps to reduce the chances of major complications of the disease to develop; ultimately there is no developed cure for the disease that can either fully stop it from taking place within the body or cure once the persons developed it. ...read more.

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