• Join over 1.2 million students every month
  • Accelerate your learning by 29%
  • Unlimited access from just £6.99 per month

Severe Combined Immunodeficiency Disorder, or SCID.

Extracts from this document...

Introduction

Severe Combined Immunodeficiency Disorder, or SCID, is a rare genetic disorder in which components of the individual's immune system is missing. This results in making the victim susceptible to disease without much chance of survival. A simple sickness could be fatal to a SCID patient. In order for these people to live, they must reside in germ-free isolation their whole lives because their immune system can't fight against bacteria or viruses that may be easy for a person with a normal immune system to overcome. Much work has been done to change the devastating effects of SCID, including gene therapy, which so far, has proven to be successful. Most cases of SCID are diagnosed within the first few months of life. They are very likely to come down with pneumonia, meningitis, or sepsis, which can be fatal diseases to the young victims. Medication is futile because their immune system does not function properly. They either have irregular or absent B-cells or T-cells, which are the white blood cells that fight off disease. ...read more.

Middle

Children with the disease usually fail to gain weight or grow normally and without proper and immediate diagnosis and treatment, the child usually will not survive longer than one year old. They develop chronic illnesses such as skin infections, yeast infections in the mouth, diarrhea, liver infections, as well as many other life threatening ailments. So they are sentenced to a life of solitude. The typically curious and adventurous child is condemned to confinement, with no friends to play with (because they may bring in outside germs) as well as having all the child's toys constantly sterilized before being able to play with, and only sporadic trips to the hospital for any breaks in the child's monotonous day. "This once-fatal disease should now be seen as a pediatric emergency, a condition that needs immediate diagnosis and treatment," said Dr. Rebecca Buckley, Duke's chief in pediatric allergy and immunology division in regard to the early detection of SCID. Parents with history of the disease in the family may get a procedure called CVS or amniocentesis done to for an early diagnosis of the child's condition. ...read more.

Conclusion

Now with more advanced technology, more and more children have been saved from this disease. In 2000, the first two cases of curing the disease by means of gene therapy in France were successful. Gene therapy is a very intricate process. It involves the removal of some stem cells from the SCID patient and in a laboratory, a normal gene is added to the abnormal stem cells. The now genetically altered stem cells reproduce, all harmless because of the addition of the normal gene, and are introduced back into the patient's bone marrow. The stem cells reproduce quickly and in a matter of weeks, the patient can now produced B-cells and T-cells independently, which fight off any foreign infections. Because this a relatively new method of curing a genetic disease, the long term effects are unknown because all the patients have this procedure done at a very early age (Tesla 1043). Luckily, the children who got gene therapy are able to live normal, healthy lives and can finally live outside the bubble. ...read more.

The above preview is unformatted text

This student written piece of work is one of many that can be found in our AS and A Level Genetics, Evolution & Biodiversity section.

Found what you're looking for?

  • Start learning 29% faster today
  • 150,000+ documents available
  • Just £6.99 a month

Not the one? Search for your essay title...
  • Join over 1.2 million students every month
  • Accelerate your learning by 29%
  • Unlimited access from just £6.99 per month

See related essaysSee related essays

Related AS and A Level Genetics, Evolution & Biodiversity essays

  1. Marked by a teacher

    An Investigation into the Mitotic Nuclear Division of Allium Sativum Root Tip Cells, and ...

    5 star(s)

    In this way, the physical structure of the cell can be further analysed to precisely pinpoint the phase of mitosis the cell is currently in. By increasing the accuracy of which the stage that cells are undergoing is identified throughout the experiment, a range of more precise and reliable conclusions and analyses can be drawn from the observed results.

  2. Parkinsons Disease

    Stem cells, however create there own ethical issues) to animals, and further on the line, of animal testing to trails on human patients. The graph below shows the stages involved in developing a new drug and is taken from the MSD website (21/3/10): (http://www.msd.com.hk/health_info/drug_education/e_ddp_introduction.html)

  1. The Biology of Autistic Spectrum Disorder and the Social Implications

    When autistic children eventually develop speech the choice of words used and the language that they use may be wrong. Other types of communicatory problems that can occur are not being able to express themselves in the way that they want to and not being able to understand gestures and facial expressions such as a sad expression.

  2. Gm foods and Gene therapy

    The society is ready to embrace technology like a distributor of specific services it offered, and does not decline a particular degree of adaptation and risk in conclusion, gave specific fundamental factors are not infringed. These factors are able to be established as: * Its foundation within the structures of

  1. Pre-implantation genetic diagnosis

    until 1980, when human In-vitro fertilisation was discovered, that humans could use PGD to help mankind cure its deadly genetic illnesses. In the UK, there has been a government-based group called the human fertilisation and the embryological authority (HFEA) that was established in 1991, this is when normal people heard

  2. Defense in the blood

    Since the title of the paper emphasized that mice are "rescued" from some ill-effects, one might be misled into thinking that the double-knockout mice were normal. They are not. As Bugge et al. (1996) state in their abstract, "Mice deficient in plasminogen and fibrinogen are phenotypically indistinguishable from fibrinogen-deficient mice."

  1. Separate but Combined

    The Olympics would continue on its steady four-year pattern unhindered by this fake war and Gene would compete in them. These sarcastic illusions allow the pair to temporarily live in a peaceful dream world amid war and the sinfulness of the truth-achieving a separate peace- but in their efforts their maturity and development of their own identities are affected.

  2. AIDS - a man-made disease?

    That in the year 1995 there will be between 10-14 million cases of AIDS and an additional 100 million people infected, 80 percent of them in the US, while a possible vaccination will not be available before 1995 by the most optimistic estimates.

  • Over 160,000 pieces
    of student written work
  • Annotated by
    experienced teachers
  • Ideas and feedback to
    improve your own work