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Thalassemia is a genetic (inherited) conditions affecting the blood. There are different types of thalassemia.

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Beta Thalassemia [Wolverhampton University] Introduction Thalassemia is a genetic (inherited) conditions affecting the blood. There are different types of thalassemia. Depending what you have, thalassemia can cause disease at all, or it could be a serious life condition requiring treatment. What causes thalassemia? The cause is genetic changes, including the genes that indicate the body as an important chemical called hemoglobin. Hemoglobin is a chemical which carries oxygen in the blood - is the one who gives blood its red color. Hemoglobin is in the cells, called "red blood cells, which are an integral part of blood. (Nassar, Rechdan, 2006) Hemoglobin is made from various parts. The main part is called "Alpha chains and beta chains, which are put together to make a molecule of hemoglobin. In thalassemia, a part of hemoglobin is damaged - usually either the alpha chain or beta-chain. This means that some of the hemoglobin is not working properly. As a result, not enough normal hemoglobin and red blood cells break down easily. This makes a person "anemic" (not in hemoglobin), with different symptoms. Meanwhile, the body trys to make more hemoglobin and red blood cells. Thus, the blood is in the 'surplus' mode, which can lead to symptoms and complications. ...read more.


This is partly from a blood transfusion, and because the thalassemia itself makes the body absorbs more iron from food. If excess iron is not removed, it can cause damage to internal organs and cause complications. Chelation helps the body rid itself of excess iron. This treatment is very important to prevent complications. There are various forms of chelation: deferiprone (Ferriprox (r)) and deferasirox (Exjade (r)) are taken into the mouth, the desferrioxamine (Desferral (r)) is given through an infusion of (a 'drip') inserted under the skin. Every form of chelation has its pros and cons, and sometimes a combination. Your doctor can discuss options and help you decide which is most suitable for you. Chelation usually begins within a year or two after the transfusion. (Aessopos, Meletis, 2007) BTM Treatment should ideally be given by experts team who have experience in the treatment of thalassemia. If this is difficult because of where you live, you should consult specialist doctors who are treating you, and you should see a specialist at least once a year. Regular reviews and surveys, in fact, it is important that your treatment fit your needs, to check for side effects and prevent complications. ...read more.


Bone problems With BTM, bone problems may arise in connection with thalassemia itself or with chelation therapy. In addition, osteoporosis (thinning of the bones) can occur at a younger age than usual. Thus, your growth (if one child) and bone health will require verification. Good reception of vitamin D and calcium helps prevent osteoporosis. Various medications may help treat osteoporosis. If your bones were severely damaged, you may need to consult specialists. (Borgna, 2007) What are the prospects for BTM? Untreated, BTM is a severe disease with worsening anemia, infections and heart failure. Without treatment, this usually leads to death before the age of five. In his address, the perspective is good because of anemia and complications can be controlled by transfusion and chelation therapy. Currently, the treatment of thalassemia, usually successfully, with patients living into adulthood and, in general, can be career, relationships and children. (Borgna, 2007) In the long run depends on how well the complications can be prevented, in particular iron overload. Early death may occur, and children sometimes develop complications such as poor growth. What makes the most difference in Outlook good chelation therapy. In addition, patients treated at the Center specialists have better outcomes. Specialist treatment is now recommended for all patients with thalassemia in the UK. In the future, probably will continue to improve because of recent advances in chelation treatment. ...read more.

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