• Join over 1.2 million students every month
  • Accelerate your learning by 29%
  • Unlimited access from just £6.99 per month

The Synthesis Of Phenacetin From p-Acetamidophenol

Extracts from this document...

Introduction

CH1751B - EXPERIMENT 15 The Synthesis Of Phenacetin From p-Acetamidophenol Introduction: "Phenacetin is an analgetic and an antipyretic reagent which acts in the body by temporaririly inhibiting prostaglandin synthesis in the central nervous system". Aim: * To synthesise Phenacetin from p-Acetamidophenol and purify it by recrystallisation. * Analyse purity of Phenacetin produced, by comparing the melting point with the literature values, the appearance and the Infrared Spectrum. Method: Sodium metal (0.6g, cut into small pieces) was cautiously placed into a dry 100cm3 round flask by taking the flask to the "sodium" balance and placing the sodium directly into the flask. A dry reflux condenser was attached and industrial methylated spirits (IMS, 15cm3) was added. A vigorous reaction occurred for 5-10 minutes under reflux until most of the sodium had dissolved. Once the solution had cooled 3.8g of p-acetamidophenol was added. ...read more.

Middle

Sodium ethoxide 2. ethyl iodide Para-acetamidophenol Phenacetin Results: Reactants Products Names Para-acetamidophenol Phenacetin Colour White powder White crystals Weight of Sample (g) 3.8 3.72 Melting point range for our experiment = 134.7 - 137.2 Percentage yield of Phenacetin from our experiment: P-acetamidophenol RAM= (2 x 16) + 14 + 9 + (12 x 8) = 151gmol-1 P-acetamidophenol moles= mass/RAM = 3.8/151 = 0.0252mol P-acetamidophenol (moles) : phenacetin (moles) = 1 : 1= 0.0250mol: 0.0250mol Phenacetin RAM= (2 x 16) + 14 + (10 x 12) + 13 = 179 Phenacetin mass (theoretical yield) = moles x RAM = 0.0250 x 179 = 4.5108g Percentage yield: (actual yield / theoretical yield) x 100 (3.72g/4.5108) x 100 = 82.34% Analysing the IR spectrum it shows that a new product (phenacetin) has been produced as there is no peak above 3500cm-1. ...read more.

Conclusion

The melting point for phenacetin in the experiment was between 134.7 - 137.2oC. Comparing that with the literature values (134-136oC), we can say that our experimental values were very similar to the literature values. However we had a greater range than the literature value range. Therefore we assume our product was pure. The IR spectrum shows characteristic peaks and readings proving that Phenacetin has been formed; showing the characteristic ether and extra carbon and no hydroxyl group. Machanism: � This "ethoxide" can deprotonate paracetamol. I Conclusion: Our final product was pure white flake crystals of phenacetin. This can be proven by the whiteness shine of the flakes and the IR spectrum. The IR spectrum showed the relevant peaks of the product phenacetin. We determined the melting point to be between 134.7 - 137.2oC, which was very similar to the literature values. This indicates the accuracy of our experiment and determination. Finally the percentage yield of 82.34% indicates that overall the experiment was successful. ...read more.

The above preview is unformatted text

This student written piece of work is one of many that can be found in our AS and A Level Organic Chemistry section.

Found what you're looking for?

  • Start learning 29% faster today
  • 150,000+ documents available
  • Just £6.99 a month

Here's what a star student thought of this essay

5 star(s)

Response to the question

The response to the question is done well throughout based on analysis, correct calculations and the depth of discussion. The main things that need work are just the structure

Read full review

Response to the question

The response to the question is done well throughout based on analysis, correct calculations and the depth of discussion. The main things that need work are just the structure

Level of analysis

The candidate uses a good introduction which concisely sets out what they're going to do and the uses of the product in the wider society. The method should really be bullet pointed with the observations next to them so it is clearer to read, although you can decipher how to carry out the experiment from the block of text provided. The diagram of the reaction and the chemical equation are all correct. The results and discussion show the experiment was successful, and show a deep scientific analysis and understanding of the experiment. Equations are correct, and decimal places are consistent. The candidate provided a well thought out discussion about why the results showed what they did. The conclusion is adequate and succinct.

Quality of writing

Could have been presented a bit more tidy with different font sizes in places and hard to read bulk paragraphs in places which should have be formatted as suggested above. Spelling, grammar and punctuation all to a good standard.


Did you find this review helpful? Join our team of reviewers and help other students learn

Reviewed by skatealexia 27/07/2012

Read less
Not the one? Search for your essay title...
  • Join over 1.2 million students every month
  • Accelerate your learning by 29%
  • Unlimited access from just £6.99 per month

See related essaysSee related essays

Related AS and A Level Organic Chemistry essays

  1. Marked by a teacher

    Experiment to Determine Acidities of Wine. The purpose of this experiment is to ...

    5 star(s)

    0.1mol l-1 Standardising the Sodium Hydroxide solution In order to standardise the NaOH solution, 20cm3 of Oxalic acid was pipetted into a volumetric flask and a few drops of phenolphthalein was added. Sodium Hydroxide was then put into a burette, and the a titration was carried out until the phenolphthalein

  2. Preparation of haloalkane. The purpose of this experiment is to prepare 2-chloro-2-methylpropane from ...

    Third, we added anhydrous sodium sulphate to the product after using the separation funnel. There might be some product that stayed with the sodium sulphate granules after pouring the product out which led to a loss of product. 2. There was a side reaction.

  1. Find the enthalpy change of combustion of a number of alcohol's' so that you ...

    This meant there was a limiting supply of oxygen resulting in incomplete combustion. Since the wick was used it meant that it also combusted and the burning of the wick creates extra energy. Thus causing a reaction to occur where bonds are broken and made.

  2. Determination of the formula of Hydrated Iron (II) Sulphate crystals

    the weight of FeSO4: Weight of water = 2.92-1.52 = 1.40g Now that I have the mass of both the FeSO4 and H2O, I can find the ratio of the two by finding the number of moles of both. FeSO4 H2O Mass (g)

  1. The aim of this experiment is to investigate the enthalpy change of combustion for ...

    However the difference between the two values does show that my results were quite accurate. I can calculate the error in my results by finding the difference between the two values and displaying this as a percentage of the calculated value.

  2. The aim of this experiment is to produce Aspirin. This is an estrification in ...

    * The crystalline mush was diluted by adding 8cm3 of cold glacial ethanoic acid using a 10cm3 pipette and cooled by placing in a water bath containing crushed ice (product becomes less soluble when its cool). This was left for approximately 10 - 15 minutes until an impure solid was formed.

  1. The aim of this experiment is to obtain the rate equation for the reaction ...

    Discussion: Comparing the stoichiometric equation with the rate equation The stoichiometric equation does not have H+ in the reactant side but with iodine in the reactant side. The rate equation has [H+], but does not have [I2]. This is because the stoichiometric equation only shows the reactant and products of

  2. investigating the amount of ascorbic acid present in fruit

    Then get medical aid immediately. Inhalation: Remove from exposure and move to fresh air immediately. If the victim is not breathing, give artificial respiration. If the victim is finding it difficult to breath, give the victim oxygen, afterwards get medical aid.

  • Over 160,000 pieces
    of student written work
  • Annotated by
    experienced teachers
  • Ideas and feedback to
    improve your own work