• Join over 1.2 million students every month
  • Accelerate your learning by 29%
  • Unlimited access from just £6.99 per month

The Synthesis Of Phenacetin From p-Acetamidophenol

Extracts from this document...

Introduction

CH1751B - EXPERIMENT 15 The Synthesis Of Phenacetin From p-Acetamidophenol Introduction: "Phenacetin is an analgetic and an antipyretic reagent which acts in the body by temporaririly inhibiting prostaglandin synthesis in the central nervous system". Aim: * To synthesise Phenacetin from p-Acetamidophenol and purify it by recrystallisation. * Analyse purity of Phenacetin produced, by comparing the melting point with the literature values, the appearance and the Infrared Spectrum. Method: Sodium metal (0.6g, cut into small pieces) was cautiously placed into a dry 100cm3 round flask by taking the flask to the "sodium" balance and placing the sodium directly into the flask. A dry reflux condenser was attached and industrial methylated spirits (IMS, 15cm3) was added. A vigorous reaction occurred for 5-10 minutes under reflux until most of the sodium had dissolved. Once the solution had cooled 3.8g of p-acetamidophenol was added. ...read more.

Middle

Sodium ethoxide 2. ethyl iodide Para-acetamidophenol Phenacetin Results: Reactants Products Names Para-acetamidophenol Phenacetin Colour White powder White crystals Weight of Sample (g) 3.8 3.72 Melting point range for our experiment = 134.7 - 137.2 Percentage yield of Phenacetin from our experiment: P-acetamidophenol RAM= (2 x 16) + 14 + 9 + (12 x 8) = 151gmol-1 P-acetamidophenol moles= mass/RAM = 3.8/151 = 0.0252mol P-acetamidophenol (moles) : phenacetin (moles) = 1 : 1= 0.0250mol: 0.0250mol Phenacetin RAM= (2 x 16) + 14 + (10 x 12) + 13 = 179 Phenacetin mass (theoretical yield) = moles x RAM = 0.0250 x 179 = 4.5108g Percentage yield: (actual yield / theoretical yield) x 100 (3.72g/4.5108) x 100 = 82.34% Analysing the IR spectrum it shows that a new product (phenacetin) has been produced as there is no peak above 3500cm-1. ...read more.

Conclusion

The melting point for phenacetin in the experiment was between 134.7 - 137.2oC. Comparing that with the literature values (134-136oC), we can say that our experimental values were very similar to the literature values. However we had a greater range than the literature value range. Therefore we assume our product was pure. The IR spectrum shows characteristic peaks and readings proving that Phenacetin has been formed; showing the characteristic ether and extra carbon and no hydroxyl group. Machanism: � This "ethoxide" can deprotonate paracetamol. I Conclusion: Our final product was pure white flake crystals of phenacetin. This can be proven by the whiteness shine of the flakes and the IR spectrum. The IR spectrum showed the relevant peaks of the product phenacetin. We determined the melting point to be between 134.7 - 137.2oC, which was very similar to the literature values. This indicates the accuracy of our experiment and determination. Finally the percentage yield of 82.34% indicates that overall the experiment was successful. ...read more.

The above preview is unformatted text

This student written piece of work is one of many that can be found in our AS and A Level Organic Chemistry section.

Found what you're looking for?

  • Start learning 29% faster today
  • 150,000+ documents available
  • Just £6.99 a month

Here's what a star student thought of this essay

5 star(s)

Response to the question

The response to the question is done well throughout based on analysis, correct calculations and the depth of discussion. The main things that need work are just the structure

Read full review

Response to the question

The response to the question is done well throughout based on analysis, correct calculations and the depth of discussion. The main things that need work are just the structure

Level of analysis

The candidate uses a good introduction which concisely sets out what they're going to do and the uses of the product in the wider society. The method should really be bullet pointed with the observations next to them so it is clearer to read, although you can decipher how to carry out the experiment from the block of text provided. The diagram of the reaction and the chemical equation are all correct. The results and discussion show the experiment was successful, and show a deep scientific analysis and understanding of the experiment. Equations are correct, and decimal places are consistent. The candidate provided a well thought out discussion about why the results showed what they did. The conclusion is adequate and succinct.

Quality of writing

Could have been presented a bit more tidy with different font sizes in places and hard to read bulk paragraphs in places which should have be formatted as suggested above. Spelling, grammar and punctuation all to a good standard.


Did you find this review helpful? Join our team of reviewers and help other students learn

Reviewed by skatealexia 27/07/2012

Read less
Not the one? Search for your essay title...
  • Join over 1.2 million students every month
  • Accelerate your learning by 29%
  • Unlimited access from just £6.99 per month

See related essaysSee related essays

Related AS and A Level Organic Chemistry essays

  1. Marked by a teacher

    Experiment to Determine Acidities of Wine. The purpose of this experiment is to ...

    5 star(s)

    At the start of the titration, the pH was read after every 3cm3 of NaOH was added, but as this came closer to the equivalence point of pH 8.2 this was read more often. A titration curve of volume against pH could then be plotted and the volume for the wine to reach a pH of 8.2 was determined.

  2. Marked by a teacher

    Reactions of aldehydes and ketones. The purpose of this experiment is to compare ...

    5 star(s)

    Discussion: Precautions: Propanone and ethanal are flammable. So, these liquids must be kept away from direct flame. Flammable Ketones and aldehydes Ketones are versatile compounds which can be converted to a number of useful functional groups through reduction, nucleophilic addition or condensation reactions. Ketones and aldehydes are important series in preparation of other compounds and they are

  1. Preparation of haloalkane. The purpose of this experiment is to prepare 2-chloro-2-methylpropane from ...

    During the transfer of the product between boiling tubes and the separation funnel, some of the cyclohexene might be vapourized and lost. The vapourization could also occur in the separation funnel where the cyclohexene turned to vapour inside the separation funnel.

  2. Determination of the formula of Hydrated Iron (II) Sulphate crystals

    the weight of FeSO4: Weight of water = 2.92-1.52 = 1.40g Now that I have the mass of both the FeSO4 and H2O, I can find the ratio of the two by finding the number of moles of both. FeSO4 H2O Mass (g)

  1. The aim of this experiment is to investigate the enthalpy change of combustion for ...

    When I calculated the bond enthalpies of both alcohols the result was the same so I felt my prediction was justified. However from looking at the results I recorded on both graphs I no longer agree with my prediction as both of the graphs tell the same story and show

  2. Enthalpy Experiment

    calculated by substituting the appropriate values in the formula of each alcohol, the RMM needs to be known to calculate how many moles are in each alcohol.

  1. Find the enthalpy change of combustion of a number of alcohol's' so that you ...

    593.89 77.8 This table clearly shows that heat loss was the main source of error. The average percentage heat loss for my experiment was 77.6%, which is a very high value and probably is the main reason for the results in graph 2.

  2. The aim of this experiment is to produce Aspirin. This is an estrification in ...

    Water * Funnel * White Tile * Goggles * Laboratory coat Preparation of 0.1 mol dm-3 sodium hydroxide solution A standard solution is one whose concentration is known exactly. Standard solutions can be prepared by weighing a mass of solid, and dissolving it with known volume of solution in a standard flask.

  • Over 160,000 pieces
    of student written work
  • Annotated by
    experienced teachers
  • Ideas and feedback to
    improve your own work