In Act 2 scene 2 Lady Macbeth has drugged the guards of Duncan's chamber.

        Macbeth wants the crown yet he fears the consequences of his terrible deed. He is not denying that being king has never crossed his mind after the witches prediction where they hailed me ''king hereafter''. But he knows that it is wrong. Lady Macbeth is much more ambitious than him and will do anything to become Queen. That is what he fears the most. He told her that ''we will speak further'' but that just makes her more anxious to become queen. Macbeth did not wish to kill Duncan. He is the King’s protector. The weird sisters do frighten him. Their prophecy was so strange. How could they possibly know about Macbeth becoming of Thane of Cawdor? Surely they must be conspiring with Satan.
           Another thing that scares Macbeth is Banquo. His oldest, loyalist friend Banquo. He is afraid that he suspects his plans to kill king Duncan. He can still remember a conversation they shared in the courtyard of his castle. He said to me'' i dreamt of the three weird sisters.   He has decided that he should kill Duncan. To him it is what he is supposed to do. If he weren’t, the witches would have never given me that prediction. But when he went into his room, and stabbed him which the dagger, he had so much blood. How can 1 man possess so much blood? So much blood. And after coming out of Duncan's chamber, he could hear voices. The porters woke up and said ''amen'' to each other. ''List'ning their fear, I could not say 'amen' when they did say 'God bless us'''. ''But wherefore could not I pronounce amen? i had most need of blessing, and amen stuck in my throat''.''Methought I heard a voice cry 'sleep no more! Macbeth does murder sleep', the innocent sleep...the death of each days life..'' Now only one thing fills his mind. Regrets. Regrets that he shall never forget.
   Macbeth has no idea on how he is going to cope with his crime. Lady Macbeth has not supported him. She merely puts him down. Lady Macbeth has been heartless and cold.  Macbeth couldn’t put the daggers back after mistakenly bringing them with him. She said: ''Infirm of purpose! Give me the daggers...I'll guild the faces of the grooms withall, for it must seem their guilt.'' Blood does not faze her at all. Macbeth fears the consequences. Will he get caught? He shall have to revisit the three weird sisters and find out that way. After all, they predicted banquo to father kings. They must be obstacles. Macbeth cannot afford to think with a heart. Now he must go. There is a frightful knocking at the gate. ''Wake Duncan with thy knocking! I would thou couldst!'