There are several different theories about the causality and development of bulimia. Bulimia may have a genetic and hereditary component aswell as a socio-environmental component. Other psychological factors involved include mood disorders and substance abuse in families of people with bulimia.
One aspect of the biological perspective suggests that people with bulimia have a low serotonin level which is a brain chemical involved with both well-being and appetite. It was also suggested that a low central dopamine level was correlated with abnormal responses to food. Jimmerson et al investigated this perspective. Cerebrospinal fluid neurotransmitter metabolite levels were studied to assess whether measures of central serotonin, dopamine, or norepinephrine function are associated with severity of abnormal eating patterns in patients with bulimia nervosa. In comparison with healthy controls , hospitalized bulimic patients with a history of binge eating more frequently than twice daily had significantly lower CSF concentrations of these brain chemicals. For the total patient group, levels of both chemicals were significantly inversely correlated with binge frequency. This may be due to the fact that low levels of serotonin are related to causing cravings for carbohydrates and subsequent binge eating. Another biological model is known as the ‘set-point’ theory (Keesey and Corbett 1984). They suggested that a part of the brain called the lateral hypothalamas which is responsible for feelings of hunger and satiety may be imbalanced in Bulimic people. According to the theory, as an individual diets and loses weight, activity in the hypothalamas drops and increases the urge to eat. This process eventually increases and usually leads to binging behaviours and the subsequent development of Bulimia. A further possible biological cause may be differences in metabolic rate. Devlin et al measured the resting metabolic rate of a group of 22 women of normal body weight with bulimia nervosa and in 19 age, sex, and weight-matched control subjects. Mean resting metabolic rate of patients was significantly lower than that of controls. This data suggest that there is a disturbance in energy regulation in bulimia nervosa. However, the origins and role of this disturbance in the pathophysiology of bulimia are unclear.