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Renal Biopsy

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Renal Biopsy A kidney biopsy (also known as a renal biopsy) is an important test to diagnose kidney disease and to monitor kidney transplants. A biopsy is a very small sample, which is used to examine kidney structure in minute detail. Urea and Creatinine Creatinine is a protein produced by muscle and released into the blood. The amount produced is relatively stable in a given person. The creatinine level in the serum is therefore determined by the rate it is being removed, which is roughly a measure of kidney function. ...read more.


In the next day the creatinine will rise to a new steady state (usually about 1.8). If both kidneys were removed (say for cancer) the creatinine would continue to rise daily until dialysis is begun. How fast it rises depends on creatinine production, which is again related to how much muscle one has. A baby may need dialysis when the creatinine reaches 2, whereas a normal adult may be able to hold off until 10, or higher. Creatinine Clearance Level Creatinine clearance is technically the amount of blood that is "cleared" of creatinine per time period. ...read more.


So why didn't the creatinine rise to only 2 when a kidney was removed? (I said it would rise to 1.8) The answer is that the remaining kidney "hyper filters" and seems to work harder, therefore kidney function is not quite halved. Usually, an adult will need dialysis because symptoms of kidney failure appear at a clearance of less than 10 ml/min. Creatinine clearance has to be measured by urine collection (usually 12 or 24 hours). It is a more precise estimate of kidney function than serum creatinine since it does not depend on the amount of muscle one has. ...read more.

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