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Investigating different types of aspirin and making aspirin.

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Jide Aspirin Introduction In this aspirin course work I will be investigating different types of aspirin and making aspirin. I will be looking at all the process taken to make aspirin and all the ingredients in aspirin. I Will be: Extracting some salicylic acid (2-hyroxy benzoic acid) from willow twigs or bark. O C OH OH 2- hydroxy benzoic acid structure We will also be learning about TLC (thin layer chromatograph), and its uses to confirm the identity of compounds. Calculating percentage yield carrying out melting points. My assignment will be structured into four tasks: Task 1- a survey of aspirin containing medicines and the medical uses of aspirin. Task 2-extracting and identifying the active chemical in willow bark Task 3- comparing methods for making and purifying aspirin Task 4- analysing Task 1- a survey of aspirin containing medicines uses of aspirin Name of aspirin Adult/children Price Dose Ingredients Contra-indicators Ascriptin Children over the age of 12 �11.49 2 caplets every 4 hours while symptoms persist, not to exceed 12 caplets in 24 hours, or as directed by a doctor for arthritis therapy. Drink a full glass of water with each dose. Aluminum Hydroxide Dried Gel (80mg), Calcium Carbonate, Magnesium Hydroxide (80mg), Aspirin (500 mg) Do not use if taking a prescription drug for anticoagulation (blood thinning), diabetes, gout, or arthritis unless directed by a doctor. Antacids may interact with certain prescription drugs. If you are presently taking a prescription drug, do not take this product without checking with your doctor or other health professional. ...read more.


* Draw a base line using a graphite pencil on the palate. It should be just above the level that will be reached by the solvent in the beaker. Apply the solution the palate using a finely drawn out glass tube. * The spot formed by the solution should be as small as possible. This is because components that do not separate well, will tend to overlap if large spots are made. * Put the solvent in the beaker and cover it with cling film or a lid. Leave for 10 minutes to allow the atmosphere to saturate. Stand the plate in the beaker and replace the lid. * When the solvent front is near the top of the plate remove the plate. Mark the position of the solvent front. Set up for the thin layer chromatography Chromatography paper lid Solvent front Baseline beaker solvent Pure 2 hydroxy benzoic acid my sample of purified 2 hydroxy benzoic Acid Task 3- comparing methods for making and purifying aspirin O COOH C OH OH O C + (CH3 CO) 2O +CH3 COOH CH3 Salicylic acid ethanoic anhydride acetylsalicylic acid (vinegar) (2-hydroxbenzoic acid) (Aspirin) Method 1 Apparatus * 2-hydroxybenzoic acid * 100ml beaker * Ethanoic anhydride * Concentrated sulphuric acid * Distilled water * 250ml beaker * Vacuum filtration equipment (buchiner funnels, buchiner flasks, tubes and Filter paper) * Ethanol * Melting point apparatus Buchner funnel setup Weigh 5.0g of 2-hydroxybenzoic acid in a 100ml beaker. Add 10ml of ethanoic anhydride with care stir to dissolve the solid. Add 12 drops of concentrated sulphuric acid stir continuously to prevent charring. ...read more.


but I think that method 1 is the best method because you don't need to heat it up for that long and the sample is pure. Evaluation The literature value of aspirin is 1350C my sample for method 1 had a melting point of 1250C, which is quite close to the literature value, but it is not the same. Maybe this is because there were some impurities in my product or I did something wrong in the preparation stages. My sample for method 2 had a melting point of 1720C, which is very far from the literature value of aspirin this is mainly because there were some impurities in my sample making the melting point higher. Comparison with industrial processes of aspirin production In a factory were they make aspirin some of the processes that require precision, strength, time or knowledge are not done by humans they are done by machines or computers. The processes that are replaced by automation are: * The equipment and chemicals are transported on conveyor belts * Computers control the temperature * All of the processes that are done over night are done by computers * All of the filtration processes are done by computers * Controlling the batch reactor * Purification Some of the advantages of using machines and computers to do most of the work is: * They are more precise * More accurate than humans * They work none stop * They are more cheaper * They are more stronger * Faster * More accurate * No errors * More durable ...read more.

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