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To determine the effectiveness of an indigestion tablet at neutralising acid.

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Introduction

To determine the effectiveness of an indigestion tablet at neutralising acid. The stomach produces Hydrochloric acid, which provides a medium for the digestion of protein by the enzyme protease. An excess of acid can lead to indigestion, many tablets are on the market to help neutralise this excess acid, but all have different ingredients. I am to find out which commercially available indigestion tablet is most effective; Brand Name Dosage Active Ingredient Other Ingredients (non-active) Do not exceed... Rennie 2 tablets Calcium Carbonate 680mg Heavy magnesium carbonate 80mg Sucrose, glucose and saccharin 16/day Andrews Antacid 1-2 tablets Calcium Carbonate 600mg Heavy magnesium carbonate 125mg Malic Acid, sugar, magnesium stearate, talc, saccharin, sodium (22mg), sodium bicarbonate 12/day Tums Antacid Calcium carbonate 500mg Sugar, glucose, starch. Talc, magnesium stearate Setlers Antacid Calcium Carbonate 500mg Sucrose, dextrose, maize starch, talc, magnesium stearate, adipic acid Asilone Antacid 1-2 tablets Dimeticone 270mg Aluminium hydroxide 500mg Sucrose, sorbitol, French chalk, menthol Bisodol 1-2 tablets Sodium bicarbonate 64mg Calcium carbonate 522mg Light magnesium carbonate 68mg Saccharin, maize starch, sucrose, calcium stearate Remegel 1 tablets Calcium Carbohydrate 800mg Glucose, butylated hydroxyanisole, methanol Milk of Magnesia 2 tablets Magnesium Hydroxide 300mg The brands in bold are the six that I have chosen to investigate Equipment As there are six different brands available, the equipment list below may need to be multiplied by 5. ...read more.

Middle

On the second titration follow the same procedure, and as you approach the equivalent point titration value, begin to add the acid one-drop at a time. The equivalent point will be the value of pH 5 on the probe, as that is a safe value of acidity in the stomach. pH 7 could have been used, however, as this is testing the tablet, in the stomach it would only raise the value not neutralise the acid, therefore, I will use pH 5. Record the amount of HCl titrated in the table below. Continue until the titrations for each tablet are within 0.1cm3 of each other. Then record the average value in the table. Save the results from the pH probe. 1st tablet 2nd tablet 3rd tablet 4th tablet 5th tablet 6th tablet Brand 1 Initial value (cm3) Final value (cm3) (Final-Initial) Titre (cm3) 2 Initial value (cm3) Final value (cm3) (Final-Initial) Titre (cm3) 3 Initial value (cm3) Final value (cm3) (Final-Initial) Titre (cm3) FINAL AVERAGE TITRATION cm3 There are a number of variables that can be altered, but most must stay the same to make it a fair test. Independent variable(s) : Ingredients in indigestion tablets Dependent variable(s): pH value Controlled variable(s) ...read more.

Conclusion

Each tablet is alkaline e.g [H+] < [OH-] The HCl is acidic e.g [H+] > [OH-] Although they will not be neutralised, a neutral solution is [H+] = [OH-] = 10-7 dm-3 (where the number of protonated waters equals the number of hydroxyl anions.) The pH is defined as the negative of the logarithm of the hydrogen ion concentration. H+ + OH- -> H2O Or more correctly H3O+ + OH- -> 2H2O The alkaline solution/suspension contains millions of hydroxide ions, this number will gradually decrease as the acid containing hydronium ions are added. Eventually, a point will be reached when the number of hydronium ions is proportional to the number of hydroxide ions originally present, at this point the pH value will be five, and the end point will have been reached. Rennie 2HCl + CaCO3 --> H2O + CO2 + CaCl2 Andrews Antacid 2HCl + CaCO3 --> H2O + CO2 + CaCl2 Asilone Antacid 3HCl + Al(OH)3 --> 3H2O + AlCl3 Bisodol 2HCl + CaCO3 --> H2O + CO2 + CaCl2 Remegel HCl + CaHCO3 --> Milk of Magnesia 3HCl + Mg(OH)3 --> 3H2O + MgCl3 ilone Antacid he pH value will be five, and the end point will have been reached.number of hydrogenium as the hydonium ions a Chemistry Practice Plan March 2003 Camilla Marcus-Dew 12.7 Dr. Pratt ...read more.

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