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Design lab - Acetylsalicylic acid (ASA) synthesis

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Introduction

´╗┐Eva Chiesa 2112-006 INTERNAL ASSESSMENT Acetylsalicylic acid synthesis Name: Eva Chiesa Candidate number: 2112-006 Examination session: May 2013 School: The English International School of Padua School number: 2112 Aim The aim of the experiment is to produce a sample of acetylsalicylic acid. Introduction Aspirin is thought to work by preventing a particular enzyme being formed at the site of the pain. This enzyme is involved in the synthesis of prostaglandins which are the ones that produce fever and inflammation, and the transmission of pain from the site of the injury to the brain. Aspirin causes many side effects, the most common is that it causes bleeding in the lining of the stomach. ...read more.

Middle

Laboratory coat 18. Gloves Procedure 1. Using a weighing boat and a digital balance measure three grams of salicylic acid and then pour them in a beaker 2. Add them to 6cm3 of acetic anhydride and to eight drops of sulphuric acid 3. Swirl the beaker to mix properly the solution 4. Then, position the beaker in a larger one full of boiling water for approximately fifteen minutes 5. Add twenty drops of freezing water to the warm solution (this will destroy the excess acetic anhydride) 6. Next, add 20cm3 of freezing water to the flask 7. Place the beaker in a larger one full of freezing water (this will speed crystallisation) 8. In the meanwhile, prepare filter paper in a funnel and position them on a conical flask 9. ...read more.

Conclusion

Let the solution cool down, crystals will reform 15. As soon as they reappear, place the beaker in another one containing freezing water (this will complete re-crystallisation) 16. Then, pour the content of the beaker in filter paper which will be already sitting in a funnel and position the funnel on a conical flask 17. After some hours you will have acetylsalicylic acid Variables 1. Controlled and independent variables 1. - Mass of salicylic acid 2. - Volume of acetic anhydride 3. - Volume of phosphoric acid 4. - Volume of ethanol 1. Dependent variables 1. - Freezing water 2. Results Physical data Molar mass/g mol-1 Density/g cm3 Salicylic acid 138.12 - Acetylsalicylic acid 180.16 - Acetic anyhydride 102.09 1.08 ________________ [1] Chemistry, Geoffrey Neuss, Oxford University Press, 2007 ...read more.

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