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THE PREPARATION OF ASPIRIN TABLETS A UNIVERSITY OF LIVERPOOL CURRICULUM ENRICHMENT PROJECT O OH C O O C CH 3 by SUPRIYA BANDARU HELEN FISHER JUDITH HYNES CATHERINE MORRIS CLARE SMITH ST JOHN RIGBY COLLEGE, ORRELL INTRODUCTION We all decided to do this project to help us with our application for university and employment, but most importantly, to help us develop and improve the essential skills of working as a team, working to our own deadlines and researching as individuals. We split our project up into different stages. Sometimes we all helped do a stage such as the presentation or the practical work, but other times we each did something different and reported back to the group during the regular meetings we had. Sections � History of Aspirin � Preparation of Aspirin � Uses and Effects of Aspirin � Tablet Making � Presentation � Evaluation SUPRIYA BANDARU HELEN FISHER JUDITH HYNES CATHERINE MORRIS CLARE SMITH ST JOHN RIGBY COLLEGE, ORRELL MAY 2000 THE HISTORY OF ASPIRIN In the last 30 years, medicines prescribed by Doctors have changed beyond all recognition. To keep up with modern medicines, Doctors have always had to turn to new drugs. One drug very old in terms of our current prescription lists has continued to flourish and has even expanded its uses. ...read more.


The product was then washed with a little cold water, to remove impurities, and transferred to a weighed watch glass and left to dry overnight. When dry, it was weighed. The products were then combined. For a product to be used as a pharmaceutical it has to be extremely pure. Unfortunately the product we obtained was still impure because it had traces of by-products and other chemicals. It had to be recrystallised by dissolving it in the minimum amount of boiling water and allowing the solution to cool. As it did, beautiful crystals appeared. The impurities were left behind in the solution. We filtered off and dried as before. The crystals looked very fluffy but when we looked at them through a magnifying glass they looked like needles. A dry, small sample was placed in a thin glass tube called a capillary tube which was then put in a melting point apparatus. The melting point was found to be 129�C. This was compared with the melting point given in a book which was 138�C . The mass of all the aspirin we produced (the yield) was found and was compared with the theoretical maximum yield we should have got. Total Yield = 8.8g Maximum yield = 28.4g Percentage yield = 31% We were amazed at how low the value was. ...read more.


We used an overhead projector to display some equations and diagrams. Our supervisor, Jonathan Hopton had photocopied them for us. SUMMARY AND EVALUATION From the project we got the opportunity to improve our skills in several areas while working as part of a team. These included... � Planning a project � Setting and meeting deadlines � Listening to the ideas of fellow team members � Having the confidence to put forward your own ideas � Problem solving � Dealing with other people � Using Information Technology We found that doing the project wasn't quite as easy as we had thought. Finding a time to meet was sometimes a problem as we weren't all doing the same course and one of us was in the Upper Sixth year. We made an excellent start, probably because we were full of enthusiasm, and were well ahead of schedule in the Autumn term. Having made the Aspirin, we eased off a bit as most of us had external modular exams to cope with. Eventually we got back together and started to make the tablets. At several times during the project we were held up waiting for information to come through from people we had written to. At times we fell a bit behind filling in our log books but when we all got together we found we could catch up. Overall, we all felt it was a worthwhile experience which would help us in our future academic and professional life. ...read more.

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