Anthelmintics are drugs that are used in the treatment of threadworm infections.

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                                ANTHELMINTICS.

Anthelmintics are drugs that are used in the treatment of threadworm infections. However for these drugs to be effective they need to be combined with hygienic measures to break the cycle of autoinfection. The different drugs used for treatment are discussed below.

                                1.MEBENDAZOLE:

This is used in the treatment of threadworm (Enterobius vermicularis), roundworm, whipworm and hookworm infections.

                        PHARMACOLOGICAL KINETICS;

This drug is a broad-spectrum agent and is one of the major groups of drugs used in the treatment of worm infections. They work by binding to free B-tubulin, inhibiting its polymerization and thus interfering with microtubule dependent glucose uptake. This effect takes time to develop and the worms may not be expelled for several days.

ASSAY; Dissolve 0.250g in 3ml of anhydrous formic acid and add 40ml of anhydrous acetic acid determining the end-point potentiometrically.

1ml of 0.1m perchloric acid is equivalent to 29.53mg of Mebendazole.

Storage: Store in a well-closed container, protect from light.

C6H13N3O3

                        2.LEVAMISOLE HYDROCHLORIDE:

This is used in the treatment of common roundworm (Ascaris lumbricoides) infections.

                        PHARMACOLOGICAL KINECTICS;

This drug has a nicotine-like action, stimulating and subsequently blocking the neuromuscular junctions. The paralyzed worms are then passed in the faeces. Ova are not killed. The drug is given orally, is rapidly absorbed and is widely distributed. It crosses the blood-brain barrier.

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ASSAY; Dissolve 0.200g in 30ml of alcohol and add 5.0ml of 0.01m hydrochloric acid. Carry out a potentiometer titration using 0.1m NaoH.Read the volume added between the two points of inflexion.1ml of 0.1m NaoH is equivalent to 24.08mg of Levamisole Hydrochloride.

Storage; Store in a well-closed container, protected from light.

C11H12N2S, HCl

                        3.PIPERAZINE PHOSPHATE;

This is used in the treatment of threadworm (Enterobius vermicularis) and roundworm (Onchocerca volvulus) infections.

                        

PHARMACOLOGICAL KINECTICS;

Its works by reversibly inhibiting neuromuscular transmission in the worm, probably by acting like GABA, the inhibitory neurotransmitter on GABA gated chloride channels in nematode ...

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