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Determination of pka of the given drug sample. The importance of pKa is that one can easily conclude how much drug is ionized and unionized. Unionized drug is better absorbed

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  • Essay length: 839 words
  • Submitted: 12/10/2011
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University Degree Chemistry

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Determination of pka of the given drug sample

INTRODUCTION:

Dissociation constant of a drug/compound is commonly refered to as pKa. It is a characteristic of drug. It is the estimation of ionized and unionized drug concentration at a particular pH. It is the pH at which 50% of drug is ionized and 50% is unionized. The dissociation constants of both acidic and basic drugs are expressed by pKa values.

The importance of pKa is that one can easily conclude how much drug is ionized and unionized. Unionized drug is better absorbed.

pKa can be calculated by following equation.

pKa = pH +log(di -d/ d- dm)

Where,

di = absorbance of the ionized species.

d = absorbance of solution tested.

dm = absorbance of the unionized species.

U.V. spectroscopy is widely used in pKa determination as we know lambda max is different for ionized and unionized drug or we can say that there is great difference between absorbance of ionized and unionized drug at a particular lambda.

MATERIALS & METHODS:

Materials:

Apparatus: 10 ml volumetric flasks, beaker, pipette

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