Biology Coursework: Does Acupuncture relieve pain?

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Does Acupuncture relieve pain?
Is this form of unconventional alternative medicine anything more than placebo effects?

Acupuncture is an alternative medicine that treats patients by insertion and manipulation of needles in the body. Its practitioners variously claim that it relieves pain, treats infertility, treats disease, prevents disease, promotes general health, or can be used for therapeutic purposes.3 However, explaining the mechanism of acupuncture using conventional science and proving that it relieves pain has proved very challenging for scientists over the decades. This coursework will attempt to explore this topic further and determine whether there is any biological proof that acupuncture reduces pain.

Ideas of what constitutes health and healing sometimes differ from concepts used in scientific, evidence based medicine. Acupuncture was developed prior to the science of human anatomy. Disease is believed to be caused, not by infectious agents, but by an imbalance of yin and yang (a metaphysical balance) caused by a "blockage" or "stagnation" of metaphysical energy known as qi (pronounced "chee") which is believed to flow within and without the body. Inserting needles into specific acupuncture points along a meridian unblocks qi and restores the body's healthy balance. 2 Jessica L (fig 1) says, “after my first session, I felt so much more balanced and in control, both mood and emotion-wise”.

Many forms of therapy, particularly for disease of the muscles, bones and joints, rely on the fact that stimulating or needling these trigger points can relieve pain.1 However, it has long been debated whether acupuncture works in a unique way or whether any benefits gained are merely down to a person's expectation that the treatment will work; known as the placebo effect. 

Scientific explanations of Acupuncture

Many western scientists explain acupuncture differently. Inserting needles at acupuncture points is suspected to stimulate the nervous system to release morphine-like substances that block pain signals. It may also trigger neurotransmitters and neurohormones, which influence such dynamic systems as circulation and the immune response.

Acupuncture Studies

Dr Bruce Pomeranz - Animal Trials

Bruce Pomeranz, a neuroscientist from the University of Toronto in Ontario, discovered in 1976 that acupuncture works as an analgesic, triggering the release of endorphins - the body's natural painkillers.4

He found that mice could tolerate pain more easily after acupuncture, and that he could block the analgesic effect by injecting the mice with naloxone before applying the needles - the substance prevents endorphins binding to nerve cells. He believes that when the needle is inserted into the muscle, it stimulates small nerve fibres which in turn send impulses to the mid-brain and hypothalamus. Endorphins in these brain regions, along with other morphine-like substances, are released to block pain. Twenty-five years later, more than 2000 experiments worldwide support the endorphin theory.2

Dr Zang-Hee - Human Trials5

Zang-Hee Cho, PhD, is Professor of Radiological Sciences at the University of California at Irvine, and Director of Functional Brain Imaging Laboratory for Acupuncture Research. Dr Cho pioneered the first Acupuncture-fMRI in 1997 and since then, has developed a number of acupuncture and fMRI related techniques. Previous to acupuncture-fMRI research, he pioneered the first Circular Ring PET scanner in the mid-70s. He has been engaged in various aspects of medical imaging, especially functional MRI imaging since the early 90s. Dr Cho is a member of US National Academy of Sciences-Institute of Medicine for his contribution to the development of PET scanner and related BGO detector. 

Acupuncture is often used for pain treatment, its effect has been suspected as a “placebo” for which biological evidence has not been shown. In addition, sceptics question the “point specificity” of acupuncture, particularly in acupuncture analgesia. Dr Zang-Hee, in the hope of dispelling these claims, conducted an experiment addressing whether pain-specific acupoints are point specific, and if evoking a “pain-like” stimulation activates the appropriate cortical areas, thereby inhibiting the perception of pain.

Figure 2 shows the various pain related brain areas; identifying the nervous system and brain regions that represent the sensation of pain. Figure 3 shows these areas after pain stimulation. Figure 4 (below) compares the activity of these brain areas without acupuncture, with real acupuncture and with sham acupuncture. The results were recorded in his journal (Volume 14 / Number 1)5.

Pain stimulation was achieved by immersing subjects’ index fingers in hot water 52ºC for 30 seconds (see fig.3). Meridian acupuncture was administered by manually twirling the needle in LR 3 for 30 seconds, needling for 30 seconds without twirling, and then removing the needle and repeating the paradigm 5 times without removing the needle. Sham acupuncture was performed with an arbitrary body point where no meridians or points passed of sufficient distance from pain relief acupoints.  The anterior cingulate cortex and thalamic areas were activated as a result of pain stimulation. Decreased activation in these areas was noted following both meridian acupuncture and sham acupuncture.

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So, is the acupuncture effect real or simply a placebo effect? If it is real, is acupuncture in reality point specific? The study attempted to answer some of these questions using functional brain imaging. The data suggests that acupuncture stimulation clearly desensitizes or reduces activation in the cortical areas that are believed to be involved with pain signal processing, thereby alleviating pain perception. The data also supports the efficacy of acupuncture in pain relief, and support the biological bases of acupuncture analgesia. Conversely, the sham acupuncture + pain study strongly suggests that the point specificity claimed by acupuncturists and by ...

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