Notes on brain scanning - PET and FMRI (Fictional Magnetic Resonance Imaging)

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PET

What is it and how does it work?

A PET (Position emission topography) scan monitors glucose metabolism in the brain. The patient is injected with a harmless dose of radioactive glucose, and the radioactive particles emitted by the glucose are detected by the PET scanner. The scans produce colored maps of brain activity.

Strengths and advantages

The PET scan has been used to diagnose abnormalities like tumors, or changes as in Alzheimer’s; to compare brain differences in normal individuals and in those with psychological disorders (neural activity is different in people with schizophrenia); and to compare sex differences.

The greatest advantage of PET (compared to MRI) is that it can record ongoing activity in the brain, such as thinking.

It helped neuroscientists to develop methods to detect the signs of Alzheimer’s disease.

It is a useful tool in screening for Alzheimer’s in people who do not yet show any symptoms of the disease.

Allows researchers to look at cross-sectional “slices” of the brain, and therefore observe deep brain structures, which earlier techniques like EEGs could not.

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Disadvantages, limitations or concerns

Because the doses of radiotracer administered are small, diagnostic nuclear medicine procedures result in relatively low radiation exposure to the patient, acceptable for diagnostic exams. Thus, the radiation risk is very low compared with the potential benefits.

Nuclear medicine diagnostic procedures have been used for more than five decades, and there are no known long-term adverse effects from such low-dose exposure.

The risks of the treatment are always weighed against the potential benefits for nuclear medicine therapeutic procedures. You will be informed of all significant risks prior to the treatment and have ...

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