According to researchers at the Center for Genomic Regulation, disruption of the circadian rhythm (the bodys natural biological clock) increases skin cells susceptibility to forming tumors and aging quicker due to the lack of cell regenera

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Rob Ranson

14 November 2011

Circadian Rhythm and the Skin

        A recent study has revealed the importance of the body’s circadian rhythm in the aging process and the regenerative capacity of skin stem cells.  According to researchers at the Center for Genomic Regulation, disruption of the circadian rhythm (the body’s natural biological clock) increases skin cells’ susceptibility to forming tumors and aging quicker due to the lack of cell regeneration.  The study, which was popularized by ScienceDaily, shines light on the importance of having a balanced sleep schedule –– something that, as a stressed college student, I seldom have the privilege to maintain.  It also raises the question of just how important having a balanced circadian rhythm is, and how adverse the absence of one can be.

        Because stem cells regulate cell replacement in tissues, they constantly reproduce cells to replenish those that have deteriorated through daily use. Correctly functioning stem cells are essential for supporting healthy tissue, including dermal tissue, during the life of an organism.  Every day, skin cells are exposed to various harmful agents such as ultraviolet rays and pathogens.  The function of the skin is to protect from such dangers, while being an impermeable barrier that separates the inside of the body from the outside world. The study showed that when a circadian rhythm is interrupted, the stem cells lose their capacity to replace dead skin cells because the genes Bmal1 and Period ½ prevent the cells from knowing when to execute the appropriate functions.

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        The circadian rhythm arranges all of our bodily functions to the natural cycles of day and night.  The process of skin rejuvenation –– which is essential to the prevention of both aging and tumor development –– is subject to such cycles of light and darkness.  The circadian rhythm regulates the behavior of stem cells so that during peak hours of light exposure, cells have to ability to protect themselves from harmful radiation; during the evening and night, when the skin is no longer being exposed to possible damage, the cycle allows the cells to divide, regenerate, and replace damaged cells ...

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