The DNA Damage Response during DNA Replication

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Arash Ghaffarpasand                                        19/01/06

             Fundamentals of Biochemistry

                           

                             The Integrative Assignment, Coursework 1

                                             Academic Session 2005/2006                                                                        


 , December 2005, Pages 568-575
Cell division, growth and death / Cell differentiation

                                             

   

  The DNA Damage Response during DNA Replication

                                      Dana Branzei and Marco Foiani

Introduction

In the cell life cycle there are some substantial stages including the progressing, stabilising and restarting of the replication fork, where endogenous and exogenous events can confront the genome integrity by stalling the fork. In order to prevent the abnormalities caused by fork stalling, which subsequently makes the chance for cancer to develop, replication forks have a special potential to resume the DNA replication process.

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In this article the way replication checkpoints participate in processing the mechanisms to stabilise, assist and organise the fork restart is shown, according to recent findings.

Endogenous and exogenous events

There are some locations in DNA called fragile sites, where the replication process slows down. The fork pausing in tRNA genes, for example, is associated with either genomic aberrations or DNA damage through mechanisms like uncoupling between strands or helicase being blocked.

In case of the replisome remained associated with the fork, some proteins such as the Rrm3 DNA helicase remove the impediments and ...

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