• Join over 1.2 million students every month
  • Accelerate your learning by 29%
  • Unlimited access from just £6.99 per month

Preparation of Aspirin.

Extracts from this document...

Introduction

Preparation of Aspirin Developed by German chemist Felix Hoffmann in 1897 as a treatment for his father's arthritis, the basic ingredients of aspirin had long been known. As long ago as the 500B.C, Hippocrates, the father of modern medicine, used ground willow bark to help pain. Willow bark contains salicin, the basis of a class of drugs called salicylates. One of the best known aromatic acetates is acetylsalicylic acid, or aspirin, which is prepared by the esterification of the phenolic hydroxyl group of salicylic acid. The key compound in the synthesis of aspirin, salicylic acid, is prepared from phenol by a process discovered over 100 years ago by the German chemist Hermann Kolbe. ...read more.

Middle

Ethanoylation of the phenolic group produces aspirin. Method; Safety glasses and protective gloves should be worn at all times as strong acid is being used and ethanoic anhydride is an irritant. Also special care must be taken when using ethanoic anhydride as it is flammable and should not be close to a flame or in high temperatures. Chemicals used; * 4cm3 of ethanoic anhydride * 2.0g of 2-hydroxybenzoic acid * 5 drops 85% Phospheric(v) acid * 42cm3 water Equipment; * safety glasses * gloves * pipette * burette * 100cm3 beaker * stirring rod * basin * ice * Suction filter * filter paper * kettle Method; Into a test tube, add 2g of 2-hydrobenzoic acid and 4cm3 of ethanoic anhydride. ...read more.

Conclusion

Allow the mixture to cool in an ice bath to complete crystallisation. Collect the product using suction filter and wash out with a little water. Purify the aspirin collected by dissolving in boiling water, re-crystallising in an ice bath, and then suction filter as before. The aspirin collected can be tested for purity by heating in capillary tubes and recording the melting point. Comparing this to the standard melting point helps to analyse the purity. Quantity on reagent required to produce a theoretical yield of 2g of aspirin; Yield / Mr of Aspirin = no. moles of aspirin needed. No. ...read more.

The above preview is unformatted text

This student written piece of work is one of many that can be found in our GCSE Aqueous Chemistry section.

Found what you're looking for?

  • Start learning 29% faster today
  • 150,000+ documents available
  • Just £6.99 a month

Not the one? Search for your essay title...
  • Join over 1.2 million students every month
  • Accelerate your learning by 29%
  • Unlimited access from just £6.99 per month

See related essaysSee related essays

Related GCSE Aqueous Chemistry essays

  1. How much Iron (II) in 100 grams of Spinach Oleracea?

    This would ensure that the solutions were at the required temperature for the titrations. Experiment Five - How much Iron (II) can be extracted from 15 grams of Spinach Oleracea when boiled in Sulphuric Acid (aq) As this was a preliminary experiment to work out the volume of spinach extract

  2. Making Aspirin.

    C2.Polymorph was successful in predicting the known crystal structure of aspirin, which contains a nonplanar conformer. Additional low-energy structures were also predicted that contained a planar conformer. While semiempirical and ab initio calculations indicated that the planar conformation is less stable than the nonplanar conformation, force field calculations suggested that the planar conformation is more stable.

  1. Preparation of aspirin - The chemical background This is the overall reaction that ...

    Weak alcohol acts as nucleophile, attacks like carbonyl carbon. After a proton transfer a water molecule is released The acid catalyst is regenerated. When Ethanoic acid is involved in esterification the process is sometimes known as ethanoylation. The ? OH group in phenol is less reactive to esterification than the ?

  2. Experiment to produce acetylsalicylic acid (Aspirin).

    This shall be judged against to the melting and yield of aspirin achieved from the industrial specification and manufacture of the product. Experimental Plan: Before beginning any of the experiments it is critical that you read the COSHHE analysis sheets for each of the chemicals that are going to be used in the experiments.

  1. Investigating different types of aspirin and making aspirin.

    With stirring until the volume is three times bigger. You must take great caution in handling the apparatus because it is extremely hot. Thin layer chromatography (TLC) Chromatography can be used to separate a mixture of components. Both qualitative and quantitative data can be obtained.

  2. the synthesis of azo dyes, aspirin and soap

    The reaction takes place under 10�C to prevent the NN, the N2 diazonium ion decomposing into N2 gas. This suggests that the delocalization of the diazonium ion bond electrons over the benzene ring is only able to stabilize the diazonium salt at cold temperatures.

  • Over 160,000 pieces
    of student written work
  • Annotated by
    experienced teachers
  • Ideas and feedback to
    improve your own work