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Spina Bifida Essay

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Assignment 1 : Spina Bifida Dita Anindya B0502333 Department for Psychology PSY 208 Dr. Hera Lukman Scientists have been mesmerized by the process of neurolation which commencing in early embryogenesis starting with the development of the neural plate culminating by the closure of the neural tube (National Institute of Health, 2007). The foremost aspect of neurolation consisted of the two most important part of human functioning, the brain and the spine, in which the time of completion of neurolation transpires on the 28th day of pregnancy (National Institute of Health, 2007). In order to achieve an appropriate closing neural tube development, the genes are needed to be actively involved regulating various functions and activities collaboratively, when the structuring mechanism is unsuccessful during the crucial period of embryogenesis, it consequences on the failure of the neural tube closing (Scottish Spina Bifida Association, 2008). Various forms of the disorder resulted from the inappropriate neural tube defects in which the major ones are usually Spina Bifida and Anencephaly (National Institute of Health, 2007). Spina Bifida medically termed as myelodysplasia is a condition of birth imperfection in the region of the spinal column in which the vertebrae fails to close as the way it should be leaving a split gap in between, originating the brain improper function (University of Virginia Health System, 2007). The severity of Spina Bifida would be depending on three categories range. ...read more.


As a result of this specific condition, there will always be a paralysis, lost of sensation, and bowel and bladder problem, Myelomeningocele would cause the individual to have a hydrocephalus causes the head to enlarge with the skull bones expanding than normal as the result of the built up CSF inside the head giving more pressure inside the head (University of Virginia Health System, 2007). Maternal nutritional factors are regarded as the most significant involvement to the complex of Spina Bifida causes specifically foremost amongst all is the supplement of folic acid (Blom, Shaw, Heijer, & Finnell, 2006). Scientists' evidence based proposes the underlying idea of maternal immune system reaction towards folate's flow of transportation, in understanding the proposing idea; scientists found maternal auto-antibody tied to folate receptors resulting of the blocking the intracellular folate uptake by target epithelial cells which consequently cause Spina Bifida (Blom, Shaw, Heijer, & Finnell, 2006). This proposing theory is in favour of the advantageous effect of supplementary folate intake. In support of this idea, the lack of folate which is accessible to the embryogenesis development to a flawed or blocked increased concentration has been major attributed to fortification of food rather than vitamin supplements (Blom, Shaw, Heijer, & Finnell, 2006). Folic Acid is the artificial form of folate used in vitamin supplements and to fortify foods, whereas folate is the natural form of vitamin B-9 component naturally occurring in foods (Morbidity and Mortality Weekly Report, 2007). ...read more.


US mainland has intensified on the importance of dietary supplements containing folic acid for most women who are planning to have babies, daily intake of 400 mg before conception could reduce the risk of Spina Bifida (Morbidity and Mortality Weekly Report, 2007). In relation to the Asian context, Asian female babies have higher prevalence on Spina Bifida, since the Westerners have amplified laws on the importance of folic acid (Morbidity and Mortality Weekly Report, 2007). The outcome of Spina Bifida is so divergent and various since the causes of Spina Bifida is not rooted to one main factor, it is a combination between the environment and genetic factors which influence the occurrence of Spina Bifida (University of Virginia Health System, 2007). Therefore, the multifactorial traits need to be taken into account when we look at the outcomes of Spina Bifida. However, Spina Bifida is a serious problem in which it involves the major and foremost part of the human functioning, which are the brain and spinal cord noted in which these two parts are the fundamental of every single nerves, and cells are connected to and where the brain is the vital part where all the neurological activities taking place (University of Virginia Health System, 2007). Hence, when the foremost parts of all neurological activity occurs with the additional of the nerves and tissues being exposed to the surrounding, it is ordinary if the outcomes of Spina Bifida are so divergent. ...read more.

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