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To prepare antifebrin using phenylammonium chloride C6H5NH3CL and Ethanoic anhydride (CH3CO)2O.

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Introduction

Preparation of the Pharmaceutical Antifebrin Antifebrin is an example of an important pharmaceutical. Chemically, antifebrin is the amide, phenylethanamide CH3CONHC6H5. Aim: To prepare antifebrin using phenylammonium chloride C6H5NH3CL and Ethanoic anhydride (CH3CO)2O. Background Knowledge: Physical state: White flakes, odourless Specific Gravity: 1.219 Sol in water: Soluble in hot water Vapour density 4.65 Auto ignition: 545 oC Stability Stable under ordinary conditions Applications: Acetanilide is used as an inhibitor or in hydrogen peroxide and stabiliser for cellulose ester varnishes. It is used as an intermediate for the synthesis of rubber accelerators, dyes and dye intermediate and camphor. It is used as a precursor in penicillin synthesis and other pharmaceuticals and its intermediates. In this report, the assessment requires use of manipulative skills and the use of the Buchner's funnel and crystallizing method.. My experience of these skills has been shown to my teacher, while performing the experiment. Fair Testing: In order to obtain valid data and ensure accurate and reliable results, I will take the following points into consideration: * When preparing the experiment, place all the equipment in line, and in a coherent and organized manner. ...read more.

Middle

Glass funnel * Sodium Ethanoate 6.0g Rubber bung * Filter paper Diagram : Diagram showing the set up of apparatus: Method: 1. Dissolve 1.0g of phenylammonium chloride in 30cm3 of water in a conical flask 2. Prepare a solution of 6.0g of sodium ethanoate in 25cm3 of water in a conical flask 3. Carefully add 2cm3 of Ethanoic anhydride to the solution of phenylammonium chloride and stir vigorously until all of the Ethanoic anhydride has dissolved. Now add the sodium ethanoate solution and continue to stir for a further three minutes. 4. The solid that has collected is a crude sample of the antifebrin. This should be collected by filtering under reduced pressure. It should then be washed with a little cold water. 5. Recrystallise the whole of your product from the minimum volume of hot water. Allow the mixture to cool and when crystallisation is complete, filter off the pure product under the reduced pressure. 6. Dry the bulk of your product in air and a small portion between the filter paper. ...read more.

Conclusion

The precision of collecting data could be improved by: * Repeating the experiment under laboratory controlled conditions and in an air tight environment * Repeating the experiment as many times as possible to gain the best possible yield without loosing too much of the product A perfect reaction would convert all of the starting material to the desired product, but very few do. My reaction only gave me a yield of 67.7%, reasons why this occurred could be as follows: * There may have been some side reactions producing by products instead of the desired chemical * Some of the product is lost during transfer of the reaction mixture from one piece of equipment to another, when the product is purified and separated. * There may be impurities in the product * Recovery of all the product from the reaction mixture is usually impossible Improving any experiment is ultimately reducing any errors within the method. The experiment could be repeated as many times as possible to gain an average set of results. Chemistry- Preparation of Antifebrin Thursday 13th Feb Deepan Patel ...read more.

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