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James Watson and Francis Cricks Discovery of DNA

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Introduction

´╗┐James Watson- Origins and education James Dewey Watson was born on April 6, 1928 in Chicago, Illinois. He was a child prodigy and attended the University of Chicago at the age of 15, where he received his Bachelor Degree of Science in Zoology in four years and went on to get his Ph.D. in Indiana University. Research and findings Watson first began molecular biology due to his inspiration from Salvador Luria. In 1948 Watson began his research at a laboratory in Indiana University, where he joined the Phage Group. Another component of chromosomes, DNA, only known purpose being as a structural role to support the proteins. However, at this time Watson, had heard and known of the Avery-MacLeod-McCarty experiment, which stated that DNA was the genetic molecule. In March 1953 Watson along with Francis Crick created the double helix model of DNA. Methods of investigation Watson used X-rays to help him deactivate bacterial viruses during a research project. Watson later used radioactive phosphate to determine the components which affected the cell during a bacteria viral infection. After learning about X-ray diffraction Watson was determined that he was on the verge of finding out about the DNA structure. ...read more.

Middle

Cooperation Franklin had worked with Maurice Wilkins when she had been studying on the B form of DNA, she had also first met James Watson in one of her seminars on the A and B forms of DNA. Before her findings on the B form of DNA were to be released, Wilkins had given them to Watson and Crick for comment, after they had read that DNA had many helixes, and information on the B form, they combined their findings on proteins and these recent findings and they constructed the first model days before Franklin would publish her findings on the B form. Awards Rosalind Franklin was awarded the Nobel Prize upon the findings of her involvement in the founding of DNA. Maurice Wilkins Maurice Wilkins was born on the 16th of December 1916 in Pongaroa in New Zealand. His family moved to Birmingham when he was six, he attended King Edwards school while he was there. Wilkins graduated in St Johns College in Cambridge where he received his bachelor in physics. Research and findings Wilkins had been studying nucleic acids and X-ray diffraction of DNA, and during one of his experiments using a carefully bundled group of DNA threads and while ...read more.

Conclusion

Research and findings When Crick had started on his works of DNA structure where he used X-ray crystallography to help him with his findings on the importance of proteins in DNA, he was also able to identify the amounts and that there was amino acids as well in DNA. In his research he found the structural integrity of the double bonds in DNA. After Maurice Wilkins had shared some information with Crick, made Crick confident that DNA was a double helix with anti-parallel chains. To help find out more Crick had to understand the Chargaff ratios. In 1953 Crick and James Watson had proposed their DNA structure after years of research. Methods of investigation Crick used X-ray crystallography to help him better understand the molecular structure of protein and DNA. He devised a new way to look at the structure of DNA called Helical diffraction. Cooperation The discovery of the DNA structure was only possible with the help and information found out by Rosalind Franklin on the B form of DNA, it was also thanks to Maurice Wilkin?s methods of X-ray diffraction that helped James Watson, Rosalind Franklin and Francis Crick found out about how DNA really looked. The DNA model only worked because James Watson and Francis Crick combined theory, modeling and experimental results to find the Structure of DNA. ...read more.

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