Case study 6 George: an unquenchable thirst
Case study 6 George, an unquenchable thirst. George was a thirty eight year old man enjoying a holiday in Spain who developed thirst and polyuria. He had no other symptoms. When he arrived home he consulted his doctor and had a urine test. There was no glycosuria. Subsequently, a blood sample was taken and the results were obtained: Serum: Calcium 3.24 mmol/l Phosphate 1.20mmol/l Alkaline phosphatise 90 iu/l Urea 10.0 mmol/l Creatinine 150 mmol/l George was a non smoker and was admitted to hospital for investigation. He had previously been well, apart from some joint pain and a painful rash on his legs several months before which has resolved spontaneously. A chest radiography showed some increased hilar shadowing but was otherwise normal. No bony abnormality was seen on skeletal radiographs. George was slightly dehydrated and was given an intravenous saline infusion. Despite a good dieresis, the serum calcium was unchanged. He was then given hydrocortisone, 40mg, three times daily, and a week later the serum calcium was 2.80 mmol/l. At this time, the result of a PTH assay on blood taken on admission became available; no PTH could be detected Introduction George, a 38 years old has presented to his GP with symptoms of thirst, polyuria and dehydration. He has a history of joint pain and a painful rash on his legs. Blood tests were carried out
Pharmacology. The use of co-beneldopa and selegiline in the treatment of Parkinsons disease
Pharmacology – Principles and Practice The use of co-beneldopa and selegiline in the treatment of Parkinson’s disease Drugs as stated by Luty and Harrison (1997) are chemical compounds which produce a desirable physiological or psychological effect when administered. This essay will discuss two different drugs which are used in the treatment of Parkinson’s disease, co-beneldopa and selegiline hydrochloride. All drugs are absorbed, distributed and then excreted (Luty and Harrison, 1997), so this essay will discuss pharmacokinetics and look at what happens to the drug once it has been administered and what effects the drug has on the body (Neal, 1992), It will also look at pharmacodynamics, the way the body affects the drug (Neal, 1992). Parkinson's disease is a neurodegenerative condition and second to Alzheimer's disease (Allcock, 2007). It is a progressive neurological condition and affects one person in every five hundred, which is about one hundred and twenty thousand people in the United Kingdom (Parkinson’s UK, 2011). Most Parkinson's disease sufferers are aged fifty or over but younger people can get it too, one in twenty is under the age of forty (Parkinson UK, 2011). An earlier onset can be due to acute encephalitis, carbon monoxide poisoning or metallic poisoning (Beckford-Bell, 2006). The disease results in motor symptoms including tremor,
Determination of Molecular Weight via SDS Page Gel. The focus of this lab is the determination of unknown proteins via molecular weight.
Olivia Takahara 09/10/2012 Chemistry 4046L Determination of Molecular Weight via SDS Page Gel Abstract Several gel separation techniques capitalize on differences in relative protein size mobility within an applied electric field. An unknown protein was mixed with sodium dodecyl sulfate (SDS) buffer, heated at 80°C, and loaded with a mixture of standard protein markers into a “pre-cast” agarose gel and “electrophoresed. The gel was developed and stained. The identity of the unknown proteins were determined by comparison to the known molecular weights of the standard protein markers. Introduction The focus of this lab is the determination of unknown proteins via molecular weight. Several unknown proteins were run in parallel with a standard ladder. Band locations between the unknowns and the ladder were compared after staining. By comparing molecular weights of the unknowns, identities were determined. Electrophoresis can take advantage of charged molecules and electric fields to separate proteins. Proteins are placed into a buffer constructed to induce negative charges to the proteins, which are loaded into a gel made of polyacrylamide. The gel provides a matrix of cross-linked acrylamide, which will separate the proteins as they travel through the matrix based on size/molecular weight, with molecules of smaller size traveling farther, faster. The
The aim of this experiment was to formulate and manufactured Aspirin 75mg tablets in direct compressions.
spacer 11 13 *1*2*3*3*3*3*4*5*5*5*5*6*7 False True 0000 2819 Introduction Marking Summary Activity Title 5004Tableting Report Groups 1 6 Direct Compression Module 5004DFACAP Submission date Monday, 26 March 2012 20:40:45 o'clock BST Marker Dr Imran Saleem Secondary comment colour codes: Author Notes You Can only be added if the My Feedback button has been activated.[a] Second marker Will only be included if second marking has occurred.[b] Marker's comment colour codes: Rating Meaning Default Not rated.[c] Poor Areas where I did not do well.[d] Satisfactory Areas where there is scope for some improvement.[e] Good Areas where I did well.[f] ________________ Liverpool John Moores University School of Pharmacy and Biomolecular Sciences 5004DFACAP PHARMACEUTICAL FORMULATION Mona Ibrahim Tablets Formulation, Manufacturing & Testing TABLETING Introduction[g] The compressed tablet is by far the most popular and versatile dosage form however it does have its drawbacks, in that it is the most technically difficult to form. Tablets are made by a process of compression. A variety of tablets exist and the type of excipients and the way in which they are incorporated vary between dependent on type and size. The powder formulation is contained within a set volume and force is applied via punches to form a solid compact. The first
Should cannabis be legalised?
Argumentative essay Scott Brown Topic: Should cannabis be legalised? Should cannabis be legalised? In the last couple of years the argument whether cannabis, a drug used by over 1.5 million people in Britain, should be legalised has raged on, and it looks unlikely to stop any time soon. Cannabis is a Class B drug (currently being downsized to Class C with no fine for small amounts for personal use). The maximum sentence for possession is five years and an unlimited fine, however police are increasingly turning a blind eye to possession of small amounts. Many MPs have voiced their opinions over the legalisation of the drug, many with contrasting views. Peter Lilley, the former deputy leader of the Conservative Party, has called for cannabis to be legalised and sold through special off-licences. However Anne Widdecombe disagrees, saying it is unlikely that legalising cannabis will get rid of any problems caused by it I personally believe that legalising cannabis will not solve the problems caused by the use of it and therefore I am against the legalisation of cannabis, and reading the evidence and arguments I have put together I am sure most people will agree. When arguing for legalisation, people point to the fact that reports from scientists claim that there is no evidence that long-term use causes lasting damage to